Pharmacology, Toxicology and Environmental Health Commons^™

Sustaining The Saco Estuary: Final Report 2015, Christine B. Feurt Ph D, Pamela A. Morgan, Mark D. O. Adams, Anna L. Bass, Carrie J. Byron, Michael C. Daley, Michael O. Esty, Noah G. Perlut, Kayla Smith, Tyler Spillane, Michelle M. Steen-Adams, James Sulikowski, Stephan I. Zeeman, Jacob Aman, Michele Dionne, Jeremy Miller, Kristin Wilson

Environmental Studies Faculty Publications

This study focuses on the Saco estuary, the tidal portion of the Saco River, which drains the largest watershed in southern Maine. With headwaters in the White Mountains of New Hampshire, the watershed encompasses more than 4,400 km², and provides clean healthy drinking water to over 100,000 people living and working in communities in southern Maine.

When the study began in 2009, very little was known about the ecology of the Saco estuary. Researchers at the University of New England and the Wells National Estuarine Research Reserve employed the process of collaborative learning to bring together people who …

Application Of A Bioenergetics Framework For Assessing Sub-Lethal Effects Of Pollutants In The Freshwater Mussel Elliptio Complanata, Christopher G. Goodchild

All Theses And Dissertations

Although biomarkers are frequently used to assess sublethal effects of contaminants, a lack of mechanistic linkages to higher-level effects limits the predictive power of biomarkers. Bioenergetics has been proposed as a framework for linking cellular effects to whole-animal effects. We investigated sublethal effects of exposure to wastewater treatment facility effluent in freshwater mussels in situ, thereby capturing ecologically relevant exposure conditions. Our study focused on the energetic biomarker AMP-activated protein kinase (AMPK), while also considering more traditional biomarkers like heat shock proteins (HSP70), and antioxidant enzymes (i.e., superoxide dismutase (SOD), glutathione-S-transferase (GST)). We examined biomarkers at mRNA and protein levels. …