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Full-Text Articles in Pharmacology, Toxicology and Environmental Health
Wheezing & Food Allergies In Infants Delivered Via Cesarean Section : The Upstate Kids Study, Temilayo Elizabeth Adeyeye
Wheezing & Food Allergies In Infants Delivered Via Cesarean Section : The Upstate Kids Study, Temilayo Elizabeth Adeyeye
Legacy Theses & Dissertations (2009 - 2024)
This dissertation sought to assess the effect of cesarean delivery (CD) on the risk of developing wheezing or food allergies in early childhood; and whether breastfeeding mediates the association between CD and the outcomes. We also aimed to highlight the differences in immunoglobulin concentrations by mode of delivery (MOD) in newborn dried blood spots (DBS), and the subsequent development of wheezing and food allergies in infants during the first three years of life. Data from the Upstate KIDS cohort was analyzed. Modified Poisson regression was used to compare the risks for wheezing and food allergies by MOD. We used a …
Organ-Specific Contribution Of P450 Enzymes To Bioactivation And Acute Respiratory Tract Toxicity Of Naphthalene, Nataliia Kovalchuk
Organ-Specific Contribution Of P450 Enzymes To Bioactivation And Acute Respiratory Tract Toxicity Of Naphthalene, Nataliia Kovalchuk
Legacy Theses & Dissertations (2009 - 2024)
Naphthalene (NA) is an omnipresent air pollutant and respiratory toxicant and a possible human lung carcinogen. NA induces cytotoxicity in airways following bioactivation by CYP (P450) enzymes. The overall goal of this study was to examine the relative contributions of hepatic and pulmonary CYPs to bioactivation, disposition and NA-induced pneumotoxicity in vivo. Substantial differences in the expression and enzymatic activity of P450s occur in various organs in human populations, which could modify susceptibility to NA-induced airway damage. The central hypothesis for this study was that NA has the potential to cause lung toxicity in humans and that the metabolism of …
Sources, Pathways, And Distribution Of Bisphenol A Diglycidyl Ether (Badge) And Its Derivatives In The Environment, Jingchuan Xue
Sources, Pathways, And Distribution Of Bisphenol A Diglycidyl Ether (Badge) And Its Derivatives In The Environment, Jingchuan Xue
Legacy Theses & Dissertations (2009 - 2024)
BADGE (bisphenol A diglycidyl ether) based epoxy resins have been used in a variety of applications since the 1940s. However, limited studies are available about the occurrence of BADGE and its derivatives (BADGEs) in the environment. The aims of this thesis were to determine the concentrations of BADGE and its derivatives in dental sealants and textile products from the U.S. to characterize the sources of these substances. Furthermore, concentrations of BADGEs in samples from various stages of waste water treatment plants (WWTPs) in the U.S. were also determined to investigate the environmental pathway and fate of these substances. BADGEs were …