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Full-Text Articles in Pharmacology, Toxicology and Environmental Health
Polychlorinated Biphenyls, Thyroid Hormones, And Neuropsychological Function Among Older Adults From Upstate New York, Eva M. Tanner
Polychlorinated Biphenyls, Thyroid Hormones, And Neuropsychological Function Among Older Adults From Upstate New York, Eva M. Tanner
Legacy Theses & Dissertations (2009 - 2024)
Polychlorinated biphenyls (PCBs) are a class of persistent organic pollutants linked to changes in cognitive function and thyroid hormone (TH) levels. However, most studies of PCBs and cognitive function were conducted among children. No studies among older adults have prospectively collected PCB and cognitive performance measurements to evaluate the association over time, and no longitudinal studies have evaluated the association between PCBs and THs over time among a non-occupationally exposed population. Further, the biological mechanism by which PCBs impact cognitive function is unknown, but may be mediated by THs. In addition, reliable self-reported survey data is necessary to obtain precise …
Perfluorinated Compounds, Thyroid Function, And Neuropsychological Status In Older Residents Of Upper Hudson River Communities, Srishti Shrestha
Perfluorinated Compounds, Thyroid Function, And Neuropsychological Status In Older Residents Of Upper Hudson River Communities, Srishti Shrestha
Legacy Theses & Dissertations (2009 - 2024)
Perfluorinated compounds (PFCs) are widespread in the environment. Minimal data exist regarding the neurotoxicity and thyroid disruptive property of PFCs in aging populations and the possible mediating effects of thyroid hormones (THs). In this study, we assessed associations among PFCs, thyroid function, and neuropsychological status, and determined if the neurotoxic effects of PFCs are mediated by changes in THs in an aging population. We measured perfluorooctanoic acid (PFOA), perfluorooctane sulfonate (PFOS), thyroid stimulating hormone (TSH), total thyroxine (T4), free T4 (fT4), and total triiodothyronine (T3) in serum and performed neuropsychological tests in men and women aged 55-74 years and living …