Pharmacology, Toxicology and Environmental Health Commons^™

Obesity Worsens Gulf War Illness Symptom Persistence Pathology By Linking Altered Gut Microbiome Species To Long-Term Gastrointestinal, Hepatic, And Neuronal Inflammation In A Mouse Model, Dipro Bose, Punnag Saha, Ayan Mondal, Brian Fanelli, Ratanesh K. Seth, Patricia Janulewicz, Kimberly Sullivan, Stephen Lasley, Ronnie Horner, Rita R. Colwell, Ashok K. Shetty, Nancy Klimas, Saurabh Chatterjee

Faculty Publications

Persistence of Gulf War illness (GWI) pathology among deployed veterans is a clinical challenge even after almost three decades. Recent studies show a higher prevalence of obesity and metabolic disturbances among Gulf War veterans primarily due to the existence of post-traumatic stress disorder (PTSD), chronic fatigue, sedentary lifestyle, and consumption of a high-carbohydrate/high-fat diet. We test the hypothesis that obesity from a Western-style diet alters host gut microbial species and worsens gastrointestinal and neuroinflammatory symptom persistence. We used a 5 month Western diet feeding in mice that received prior Gulf War (GW) chemical exposure to mimic the home phase obese …

Lipocalin 2 Induces Neuroinflammation And Blood-Brain Barrier Dysfunction Through Liver-Brain Axis In Murine Model Of Nonalcoholic Steatohepatitis, Ayan Mondal, Dipro Bose, Punnag Saha, Sutapa Sarkar, Ratanesh K. Seth, Diana Kimono, Muayad Albadrani, Mitzi Nagarkatti, Prakash Nagarkatti, Saurabh Chatterjee

Faculty Publications

BACKGROUND:

Recent clinical and basic research implicated a strong correlation between NAFLD/NASH phenotypes with ectopic manifestations including neuroinflammation and neurodegeneration, but the mediators and critical pathways involved are not well understood. Lipocalin 2 (Lcn2) is one of the important mediators exclusively produced in the liver and circulation during NASH pathology.

METHODS:

Using murine model of NASH, we studied the role of Lcn2 as a potent mediator of neuroinflammation and neurodegeneration in NASH pathology via the liver-brain axis. RESULTS: Results showed that high circulatory Lcn2 activated 24p3R (Lipocalin2 receptor) in the brain and induced the release of high mobility group box …