Pharmacology, Toxicology and Environmental Health Commons^™

Consumption Of Low-Moderate Level Arsenic Contaminated Water Does Not Increase Spontaneous Pregnancy Loss: A Case Control Study, Michael S. Bloom, Iulian Neamtiu, Simona Surdu, Cristian Pop, Ioana-Rodica Lupsa, Doru Anastasiu, Edward F. Fitzgerald, Eugen S. Gurzau

Environmental Health Sciences Faculty Scholarship

Previous work suggests an increased risk for spontaneous pregnancy loss linked to high levels of inorganic arsenic (iAs) in drinking water sources (>10 μg/L). However, there has been little focus to date on the impact of low-moderate levels of iAs in drinking water (<10 >μg/L). To address this data gap we conducted a hospital-based case–control study in Timis County, Romania.

Thyroid Function And Perfluoroalkyl Acids In Children Living Near A Chemical Plant, Maria-Jose Lopez-Espinosa, Debapriya Mondal, Ben Armstrong, Michael S. Bloom, Tony Fletcher

Environmental Health Sciences Faculty Scholarship

Background: Animal studies suggest that some perfluoroalkyl acids (PFAAs), including perfluorooctanoate (PFOA), perfluorooctane sulfonate (PFOS), and perfluorononanoic acid (PFNA) may impair thyroid function. Epidemiological findings, mostly related to adults, are inconsistent.

Objectives: We investigated whether concentrations of PFAAs were associated with thyroid function among 10,725 children (1–17 years of age) living near a Teflon manufacturing facility in the Mid-Ohio Valley (USA).

Methods: Serum levels of thyroid-stimulating hormone (TSH), total thyroxine (TT4), and PFAAs were measured during 2005–2006, and information on diagnosed thyroid disease was collected by questionnaire. Modeled in utero PFOA concentrations were based on historical information on PFOA releases, …

Maternal Serum Polychlorinated Biphenyl Concentrations Across Critical Windows Of Human Development, Michael S. Bloom, Germaine M. Buck-Louis, Aiyi Liu

Environmental Health Sciences Faculty Scholarship

Background

Few data are available on polychlorinated biphenyl (PCB) concentrations over critical windows of human reproduction and development inclusive of the periconception window.

Objectives

Our goal was to measure changes in PCB concentrations from preconception to pregnancy, through pregnancy, or after a year without becoming pregnant.

Methods

Seventy-nine women planning pregnancies were prospectively enrolled and followed for up to 12 menstrual cycles of attempting pregnancy. Blood specimens were obtained from participating women preconceptionally (n = 79), after a positive pregnancy test leading to a live birth (n = 54) or pregnancy loss (n= 10), at approximately …