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Full-Text Articles in Other Life Sciences
Alternative Polyadenylation Modulates Expression Of Pro-Fibrotic Proteins And Contributes To Lung Fibrosis, Junsuk Ko
Dissertations & Theses (Open Access)
Idiopathic pulmonary fibrosis (IPF) is a chronic lung disease which affects about 5 to 8 million individuals in the world. Despite the high prevalence, there is currently no cure for IPF, and the cause of this disease is still unclear. Our laboratory and collaborators have shown that nudix hydrolase 21 (NUDT21, which is also known as cleavage factor 25, CFIm25) is a key regulator of alternative polyadenylation (APA). NUDT21 depletion causes 3’UTR shortening via APA leading to enhanced mRNA stability and protein translation. This NUDT21 reduction promotes tumor growth in glioblastoma by enhancing expression of oncogenes. Cancer and IPF share …
Faculty Spotlight—Dr. Phil Danielson, Hannah Stanley, William Moody
Faculty Spotlight—Dr. Phil Danielson, Hannah Stanley, William Moody
DU Undergraduate Research Journal Archive
Interview with Dr. Phil Danielson
Faculty Spotlight—Dr. Robert Dores, Anit Tyagi, William Moody
Faculty Spotlight—Dr. Robert Dores, Anit Tyagi, William Moody
DU Undergraduate Research Journal Archive
Robert Dores Interview
Edited by Will Moody