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Full-Text Articles in Nutrition

Vitamin K2 (Menaquinone) Supplementation And Its Benefits In Cardiovascular Disease, Osteoporosis, And Cancer, Grant S. Buchanan, Md, Thomas Melvin, Brandon Merritt, Charles Bishop, Md, Franklin D. Shuler, Md, Phd Oct 2016

Vitamin K2 (Menaquinone) Supplementation And Its Benefits In Cardiovascular Disease, Osteoporosis, And Cancer, Grant S. Buchanan, Md, Thomas Melvin, Brandon Merritt, Charles Bishop, Md, Franklin D. Shuler, Md, Phd

Franklin D. Shuler

Vitamin K is known to play an essential role in the coagulation cascade; however, a growing body of research has found that a subtype of this vitamin, vitamin K2 (menaquinone) may have a beneficial effect in osteoporosis, cardiovascular disease, and cancer. This purpose of this article is to provide a comprehensive review of recent literature regarding menaquinone and its role in human health. This review discusses the physiology of menaquinone, its clinical benefits in cardiovascular disease, osteoporosis, and cancer, and how it may interact with certain medications. The authors conclude that menaquinone supplementation has been shown to improve carboxylation of …


Vitamin K2 (Menaquinone) Supplementation And Its Benefits In Cardiovascular Disease, Osteoporosis, And Cancer, Grant S. Buchanan, Md, Thomas Melvin, Brandon Merritt, Charles Bishop, Md, Franklin D. Shuler, Md, Phd Jul 2016

Vitamin K2 (Menaquinone) Supplementation And Its Benefits In Cardiovascular Disease, Osteoporosis, And Cancer, Grant S. Buchanan, Md, Thomas Melvin, Brandon Merritt, Charles Bishop, Md, Franklin D. Shuler, Md, Phd

Marshall Journal of Medicine

Vitamin K is known to play an essential role in the coagulation cascade; however, a growing body of research has found that a subtype of this vitamin, vitamin K2 (menaquinone) may have a beneficial effect in osteoporosis, cardiovascular disease, and cancer. This purpose of this article is to provide a comprehensive review of recent literature regarding menaquinone and its role in human health. This review discusses the physiology of menaquinone, its clinical benefits in cardiovascular disease, osteoporosis, and cancer, and how it may interact with certain medications. The authors conclude that menaquinone supplementation has been shown to improve carboxylation …


A Dietary Approach To Cardiovascular Disease And Cancer: Does A Plant Based Diet Help Prevent And Reverse Cardiovascular Disease And Cancer?, Chana Wircberg Jan 2016

A Dietary Approach To Cardiovascular Disease And Cancer: Does A Plant Based Diet Help Prevent And Reverse Cardiovascular Disease And Cancer?, Chana Wircberg

The Science Journal of the Lander College of Arts and Sciences

Modern Western societies seem to suffer from a veritable epidemic of serious diseases, two of the most serious of which are cardiovascular disease and cancer. In contrast, hunter and gatherer groups have a very low incidence of such diseases. Despite the diversity of hunter and gather diets, they all share the same characteristic: the absence of a Western diet. This suggests that there is something uniquely inflammatory about a Western diet, which is high in both fats and carbohydrates. Departures from a Western diet appear to result in better health. Experimental studies have shown that heart disease can be reversed …


The Impact Of Folate Restriction On Cancer And Aging: A Mechanistic Analysis, Safa Beydoun Jan 2016

The Impact Of Folate Restriction On Cancer And Aging: A Mechanistic Analysis, Safa Beydoun

Wayne State University Dissertations

Aging is a multifactorial process associated with alterations in several physiological functions. It increases susceptibility to disease and ultimately results in mortality. Since the associated diseases of aging are highly prevalent in the geriatric population, targeting the aging process as a whole may provide a better way to delay these age related diseases, in turn delaying aging. Various interventions have been shown to delay aging and age related diseases. They impact a major nutrient sensing pathway, mTOR. mTOR signaling is altered in many cancers and its downregulation was shown to delay aging. Other interventions extend lifespan by altering the one …


Cranberries And Cancer: An Update Of Preclinical Studies Evaluating The Cancer Inhibitory Potential Of Cranberry And Cranberry Derived Constituents, Katherine M. Weh, Jennifer L. Clarke, Laura A. Kresty Jan 2016

Cranberries And Cancer: An Update Of Preclinical Studies Evaluating The Cancer Inhibitory Potential Of Cranberry And Cranberry Derived Constituents, Katherine M. Weh, Jennifer L. Clarke, Laura A. Kresty

Department of Nutrition and Health Sciences: Faculty Publications

Cranberries are rich in bioactive constituents reported to influence a variety of health benefits, ranging from improved immune function and decreased infections to reduced cardiovascular disease and more recently cancer inhibition. A review of cranberry research targeting cancer revealed positive effects of cranberries or cranberry derived constituents against 17 different cancers utilizing a variety of in vitro techniques, whereas in vivo studies supported the inhibitory action of cranberries toward cancers of the esophagus, stomach, colon, bladder, prostate, glioblastoma and lymphoma. Mechanisms of cranberry-linked cancer inhibition include cellular death induction via apoptosis, necrosis and autophagy; reduction of cellular proliferation; alterations in …