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Proalgazyme Subfraction Improves The Lipoprotein Profile Of Hypercholesterolemic Hamsters, While Inhibiting Production Of Betaine, Carnitine, And Choline Metabolites, Andreea Geamanu, Arvind Goja, Nadia Saadat, Pramod Khosla, Smiti V. Gupta
Proalgazyme Subfraction Improves The Lipoprotein Profile Of Hypercholesterolemic Hamsters, While Inhibiting Production Of Betaine, Carnitine, And Choline Metabolites, Andreea Geamanu, Arvind Goja, Nadia Saadat, Pramod Khosla, Smiti V. Gupta
Wayne State University Associated BioMed Central Scholarship
Abstract
Background
Previously, we reported that ProAlgaZyme (PAZ) and its biologically active fraction improved plasma lipids in hypercholesterolemic hamsters, by significantly increasing the high density lipoprotein cholesterol (HDL-C) while reducing non-HDL cholesterol and the ratio of total cholesterol/HDL-C. Moreover, hepatic mRNA expression of genes involved in HDL/reverse cholesterol transport were significantly increased, while cholesteryl ester transfer protein (CETP) expression was partially inhibited. In the current study, we investigated the therapeutic efficacy of the biologically active fraction of PAZ (BaP) on the plasma lipid and plasma metabolomic profiles in diet induced hypercholesterolemic hamsters.
Methods
Fifty male Golden Syrian hamsters were fed …
The Effect Of Proalgazyme And Its Subfractions On Lipid Metabolism In Diet Induced Hypercholesterolemic Hamsters: Correlation With Plasma Metabolomic Profile, Andreea Geamanu
Wayne State University Dissertations
ABSTRACT
THE EFFECT OF PROALGAZYME AND ITS SUBFRACTIONS ON LIPID METABOLISM IN DIET INDUCED HYPERCHOLESTEROLEMIC HAMSTRES:
CORREALTION WITH PLASMA METABOLOMIC PROFILE
by
ANDREEA GEAMANU
December 2013
Advisor: Dr. Smiti Gupta
Major: Nutrition and Food Science
Degree: Doctor of Philosophy
Background: Plasma HDL cholesterol levels are inversely related to cardiovascular disease, which is the leading cause of death worldwide. This study investigated the preventative effect of an algae infusion, ProAlgaZyme (PAZ) and its subfractions (F1, F2, F3, F4) on plasma HDL in a hamster model. Further, the study aimed to identify the biologically active fraction of PAZ and to determine the …