Open Access. Powered by Scholars. Published by Universities.®

Nutrition Commons™

Open Access. Powered by Scholars. Published by Universities.®

Nutritional Epidemiology

Cancer

Articles 1 - 2 of 2

Full-Text Articles in Nutrition

Clinical And Therapeutic Significance Of Obesity In Melanoma, Jennifer L. Mcquade Aug 2017

Clinical And Therapeutic Significance Of Obesity In Melanoma, Jennifer L. Mcquade

Dissertations & Theses (Open Access)

While the FDA approval of targeted and immune therapies in metastatic melanoma (MM) have dramatically improved outcomes in this disease, de novo and/or acquired resistance can limit the clinical benefit of these agents. The IGF-1/PI3K/AKT pathway has been implicated in resistance to both targeted and immune therapy. The IGF-1/PI3K/AKT pathway has also been shown to play a key role in the pathogenesis of obesity in other malignancies. To date, the impact of energy balance on clinical outcomes and therapeutic response in MM has not been studied. I hypothesized that energy balance would impact the molecular biology, behavior, and drug sensitivity …

Go to article

Lifestyle, Anthropometric, And Obesity-Related Physiologic Determinants Of Insulin-Like Growth Factor-1 In The Third National Health And Nutrition Examination Survey (1988-1994).Pdf, Niyati Parekh, Calpurnyia B. Roberts, Maya Vadiveloo, Thanusha Puvananayagam, Jeanine Albu, Grace L. Lu-Yao Dec 2009

Lifestyle, Anthropometric, And Obesity-Related Physiologic Determinants Of Insulin-Like Growth Factor-1 In The Third National Health And Nutrition Examination Survey (1988-1994).Pdf, Niyati Parekh, Calpurnyia B. Roberts, Maya Vadiveloo, Thanusha Puvananayagam, Jeanine Albu, Grace L. Lu-Yao

Maya Vadiveloo

PURPOSE: Epidemiologic studies suggest that insulin-like growth factor-1 (IGF-1) is associated with obesity and, more recently, cancer. This study investigates multiple lifestyle, physiologic, and anthropometric determinants of circulating IGF-1 concentrations.
METHODS: Nationally representative data were used from the cross-sectional Third National Health and Nutrition Examination (NHANES III, 1988–1994) survey, which measured IGF-1 concentrations in blood, from a subsample of participants who were examined in the morning. After exclusion of persons with missing data, 6,058 men and women 20 years of age or older were included in the study.
RESULTS: The mean IGF-1 concentrations were 260 ng/mL in …

Go to article