Open Access. Powered by Scholars. Published by Universities.®
- Keyword
-
- 4-Acetylantroquinonol B (1)
- Antrodia camphorata (1)
- Antroquinonol (1)
- BMI (1)
- Breast cancer (1)
-
- Cancer chemoprevention (1)
- Combination (1)
- Curcumin (1)
- Dietary bioactive components (1)
- Epigenetics (1)
- Flavonoids (1)
- Folate (1)
- Histone Acetylation (1)
- Immunotherapy (1)
- Inflammation (1)
- Methylation (1)
- Premenopausal breast cancer (1)
- SFRP1 (1)
- Sulforaphane (1)
- Synergy (1)
- Trichostatin A (1)
- Vitamin D (1)
- Publication
Articles 1 - 4 of 4
Full-Text Articles in Nutrition
Combination Regimens Using Dietary Components For The Chemoprevention Of Colorectal Cancer And Inflammation, Christina Dimarco-Crook
Combination Regimens Using Dietary Components For The Chemoprevention Of Colorectal Cancer And Inflammation, Christina Dimarco-Crook
Doctoral Dissertations
ABSTRACT COMBINATION REGIMENS USING DIETARY COMPONENTS FOR THE CHEMOPREVENTION OF COLORECTAL CANCER AND INFLAMMATION September 2018 CHRISTINA DIMARCO-CROOK, B.S., IMMACULATA UNIVERSITY M.S., DREXEL UNIVERSITY Ph.D., UNIVERSITY OF MASSACHUSETTS AMHERST Directed by: Professor Hang Xiao Dietary components have been found to effectively modulate multiple deregulated signaling pathways associated with the initiation and progression of carcinogenesis and inflammation in cellular and animal models. However, clinical studies have shown mixed results when examining the efficacy of individual dietary components, perhaps suggestive of the synergism that exists between multiple components within a particular food and the diet as a whole. Additional research is needed …
Influences Of Antroquinonol And 4-Acetylantroquinonol B On Inflammatory Tumorigenesis In The Mcf-7 Breast Cancer Cell Line With Or Without Tnf-Α Stimulation, Ting-Chun Lin
Masters Theses
Breast cancer (BC) is one of the most common cancers among women worldwide that ~25% of new cancer cases diagnosed every year would be BC; moreover, ~15% of cancer deaths per year caused by BC makes it the leading cause of cancer death among women worldwide. To date, though the cause of a large proportion of BC are still unclear, recent studies have revealed that a supportive breast tissue microenvironment is critical for the development and progression of BC, especially the communication with immune cells within breast tissue. Therefore, breast inflammatory microenvironment is currently received a substantial attention in the …
Epigenetic Modification Of Vitamin D-Induced Gene Expression In Human Colorectal And Breast Cancer Cell Lines, Sharmin Hossain
Epigenetic Modification Of Vitamin D-Induced Gene Expression In Human Colorectal And Breast Cancer Cell Lines, Sharmin Hossain
Doctoral Dissertations
Epigenetics is the study of the regulation of genes that is not dependent on nucleotide sequence. This may include heritable changes in gene activity and expression but also those that are not heritable. In recent years, epigenetic researchers have made great strides in understanding the molecular mechanisms behind cellular functions in response to diet, exercise, and other lifestyle modifications, like methylation, histone modification etc. It is now known that the epigenome is critical to healthy human development in addition to genetics, and dietary factors can modulate epigenetic alterations in cells. The classic view of cancer etiology is that genetic alterations …
Impact Of Bodyweight On Tissue-Specific Folate Status, Genome Wide And Gene-Specific Dna Methylation In Normal Breast Tissues From Premenopausal Women, Armina-Lyn Frederick
Impact Of Bodyweight On Tissue-Specific Folate Status, Genome Wide And Gene-Specific Dna Methylation In Normal Breast Tissues From Premenopausal Women, Armina-Lyn Frederick
Masters Theses
Obesity has reached an epidemic level in the United States. A number of epidemiological studies have established obesity as a critical risk factor for postmenopausal breast cancer (post-BC), whereas a reverse association holds prior to menopause. A significant scientific gap exists in understanding the mechanism(s) underpinning this epidemiological phenomenon, particularly the reverse association between obesity and premenopausal breast cancer (pre-BC). This study aimed to understand how folate metabolism and DNA methylation informs the association between obesity and pre-BC. Fifty normal breast tissue samples were collected from premenopausal women who underwent reduction mammoplasty. We developed and measured the breast tissue folate …