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Memory

2018

Articles 1 - 8 of 8

Full-Text Articles in Neuroscience and Neurobiology

Contextual Fear Memory Modulates Psd95 Phosphorylation, Ampar Subunits, Pkmζ And Pi3k Differentially Between Adult And Juvenile Rats, Roseanna M. Zanca, Shirley Sanay, Jorge A. Avila, Edgar Rodriguez, Harry N. Shair, Peter A. Serrano Nov 2018

Contextual Fear Memory Modulates Psd95 Phosphorylation, Ampar Subunits, Pkmζ And Pi3k Differentially Between Adult And Juvenile Rats, Roseanna M. Zanca, Shirley Sanay, Jorge A. Avila, Edgar Rodriguez, Harry N. Shair, Peter A. Serrano

Publications and Research

It is well known that young organisms do not maintain memories as long as adults, but the mechanisms for this ontogenetic difference are undetermined. Previous work has revealed that the α-amino-3-hydroxy-5-methyl-4isoxazolepropionic acidreceptor (AMPAr)subunits aretraffickedinto the synaptic membranefollowing memory retrieval in adults. Additionally, phosphorylated PSD-95-pS295 promotes AMPAr stabilization at the synapse. We investigated these plasticity related proteins as potential mediators in the differential contextual stress memory retrieval capabilities observed between adult and juvenile rats. Rats were assigned to either pedestal stress (1h) or no stress control (home cage). Each animal was placed alone in an open field for 5minat the base …

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The Inter-Subject Correlation Of Eeg In Response To Naturalistic Stimuli, Samantha S. Cohen Sep 2018

The Inter-Subject Correlation Of Eeg In Response To Naturalistic Stimuli, Samantha S. Cohen

Dissertations, Theses, and Capstone Projects

Inter-subject correlation is a measure of the similarity of the brain activity of a group of people as they respond to the same naturalistic stimulus, typically a story or video, meant to simulate a real world experience. This thesis tests the hypothesis that the correlation of the brain responses of a group of people is indicative of stimulus engagement. The rationale is that the content of the stimulus drives brain activity in a consistent manner, while internal thoughts are divergent and result in uncorrelated activity. The inter-subject correlation (ISC) of neural responses have previously been assessed with fMRI, EEG, and …

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The Relationship Between Cognitive And Neural Bases Of Metamemory Judgments, Alexandra M. Gaynor Sep 2018

The Relationship Between Cognitive And Neural Bases Of Metamemory Judgments, Alexandra M. Gaynor

Dissertations, Theses, and Capstone Projects

Metamemory monitoring, the process of making subjective assessments of the status of one’s own memory, is crucial to guiding behavior and effective learning. Past cognitive research has shown that subjective confidence judgments are inferential in nature, and based on cues available at the time of the judgment. When confidence is based on cues that are related to objective memory performance, metamemory accuracy is high. However, past studies have shown that metamemory monitoring tends to be inaccurate because individuals base their confidence on information that is not predictive of memory success, such as the fluency with which items were encoded during …

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Neural Correlates Of Memory Decisions Made In The Face Of Conflict, Elaine Mahoney Aug 2018

Neural Correlates Of Memory Decisions Made In The Face Of Conflict, Elaine Mahoney

Theses and Dissertations

We’ve all experienced moments where, for some reason or another, we don’t want to reveal to others what we truly know. The current experiment investigated questions about the behavioral and neural correlates of these types of memory decisions made in the face of a conflicting goal. Participants in this experiment studied several scene-face pairs and were tested with three-face displays preceded by studied scene cues. They were instructed to indicate whether the three-face display contained the matching associate or not. Critically, half of the participants were instructed to simulate feigned memory impairment (i.e. simulators), while the remainder were instructed to …

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Defining The Radioresponse Of Mossy Cells, Devon Ivy Jun 2018

Defining The Radioresponse Of Mossy Cells, Devon Ivy

Electronic Theses, Projects, and Dissertations

Clinical radiotherapy is used to treat a variety of brain tumors within the central nervous system. While effective, it can result in progressive and debilitating cognitive impairment that can diminish quality of life. These impairments have been linked to hippocampal dysfunction and corresponding deficits in spatial learning and memory. Mossy cells are a major population of excitatory neurons located within the dentate hilus and highly involved in hippocampal circuitry. They play critical roles in spatial navigation, neurogenesis, memory, and are particularly vulnerable to a variety of neurotoxic insults. However, their sensitivity to ionizing radiation has yet to be investigated in …

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Moderate Prenatal Alcohol Exposure Impairs Performance In An Object-Place-Paired-Associate Task, Lilliana May Sanchez Apr 2018

Moderate Prenatal Alcohol Exposure Impairs Performance In An Object-Place-Paired-Associate Task, Lilliana May Sanchez

Psychology ETDs

Memory impairments, including spatial and object processing, are often observed in individuals with Fetal Alcohol Spectrum Disorder. Much attention has been directed towards the hippocampus, which displays significant alterations after moderate prenatal alcohol exposure (PAE). In the present study, we tested a moderate PAE rat model in an object-place-paired-associate (OPPA) task, previously shown to require hippocampal processing. The OPPA task was composed of training rats to discriminate between an identical pair of objects presented in 180° opposite arms of a radial arm maze. Animals were given a total of 10 trials per day over 14 consecutive days of training and …

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Assessing The Long-Term Sequelae Of Mild Traumatic Brain Injury, Janna Mantua Mar 2018

Assessing The Long-Term Sequelae Of Mild Traumatic Brain Injury, Janna Mantua

Doctoral Dissertations

A mild traumatic brain injury (mTBI), also known as a concussion, is defined as an injury that results in an alteration of consciousness or mental status. Previous studies have shown mTBI populations experience a number of chronic (> 1 year) symptoms, such as sleep disturbances (e.g., sleep stage alterations), mood alterations (e.g., depressive symptoms), and cognitive alterations (e.g., poor concentration). The three chapters of this dissertation sought to explore these long-term sequelae and the possible interrelations between them. In the first experiment, sleep-dependent memory consolidation of neutral stimuli was probed in a chronic mTBI sample and a control, uninjured sample. …

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Testing The Network Reset Hypothesis: Noradrenergic Modulation Of Hippocampal Representations, Stephanie L. Grella Jan 2018

Testing The Network Reset Hypothesis: Noradrenergic Modulation Of Hippocampal Representations, Stephanie L. Grella

Theses and Dissertations (Comprehensive)

The locus coeruleus (LC) responds to salience cues, including novelty, and sends a major noradrenergic projection to the hippocampal formation (HF). Novelty-associated LC activation may help to sculpt contextual representations in the HF, but modulatory influence of norepinephrine (NE) over HF representations remains poorly understood. One possible mechanism is that NE provides a “reset” signal causing the HF to recruit distinct neural populations, thereby providing a molecular switch to dictate if hippocampal circuits should generate new representations or update existing ones to incorporate novel information. This hypothesis suggests that NE release should cause the HF to recruit a unique population …

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