Neuroscience and Neurobiology Commons^™

Gpr171 Modulates Mood, Consummatory Behaviors, And Morphine Antinociception In A Sexually Dimorphic Pattern In Mice, Megan C. Raddatz

All Graduate Theses and Dissertations, Fall 2023 to Present

Receptors in the brain influence everything from complex behaviors related to mood, all the way to simple physiological functions like the way a person moves. Receptors are activated or inactivated by chemicals or hormones that the body produces or that are created to mimic the body’s natural chemicals. Of the hundreds of receptors in the brain, GPR171 is particularly interesting because new drugs have been created to activate or block the receptor, and are being proposed for the treatment of different disorders, particularly disorders related to pain. GPR171 has been shown to affect pain behaviors, eating, and mood-related behaviors, but …

Role Of Proneurotrophin-P75ntr Signaling In A Mouse Model Of Depression, Kirsten Hodgson

All Graduate Theses and Dissertations, Fall 2023 to Present

Major depressive disorder, or depression, is among the leading causes of disability globally. Despite being a large public health challenge, depression remains difficult to treat as the underlying biology is still unknown and the currently available treatments are limited in effectiveness. This experiment was to test the efficacy of the drug LM11A-31, which works on the signaling pathway of proneurotrophin-p75NTR, a pathway that is not targeted by any currently used antidepressants. Male mice underwent a repeated forced swim, with all the mice receiving saline the first two days and then half the mice receiving saline and half receiving LM11A-31 before …

Prospective Associations Of Fish Consumption In Cognitive Function And Depressive Symptoms Among Puerto Rican Adults, Johanna Grace Koroma

Honors Theses and Capstones

Johanna Koroma, Anne Bodenrader, and Sherman Bigornia

Objectives

Fish intake has been linked to certain neural benefits, specifically in slowing cognitive decline and attenuating depressive symptoms. However, existing evidence is conflicting and insufficient. The present study aimed to investigate the association of fish consumption with depressive symptoms and cognitive function among Puerto Rican adults.

Methods

Data is acquired from the Boston Puerto Rican Health Study, comprised of 1517 adults residing in the Boston Metro Area. Dietary patterns were evaluated using a validated food frequency questionnaire (FFQ) with follow-up surveys conducted 2 years from baseline. Consumption was organized into quartiles based …

Testosterone Administration In Premenopausal Women, Kaeli Nichol Shockley

Graduate Student Theses, Dissertations, & Professional Papers

Testosterone administration is a relatively uncommon practice in the United States. Women are at risk of having health issues that could be remedied by low-dose testosterone administration via transdermal patch or topical cream. This paper explores the potential health and wellness benefits of administering low-dose testosterone to premenopausal women. Low-dose Testosterone may improve depression scores as well as upregulate markers of bone formation in women with anorexia nervosa. Higher testosterone was associated with increased muscle mass and muscular strength in collegiate female athletes. Testosterone given at lower doses increases muscle mass and exercise performance in college-age women. Overall, testosterone supplementation …