Neuroscience and Neurobiology Commons^™

Pattern Recognition Receptors, Immune Proteins, And Nf-Κb Signaling Regulate Behaviors Associated With Aging Phenotypes, Nicholas W. Dekorver

Theses & Dissertations

The aging process is accompanied by functional impairments, including reduced locomotor function, fragmentation of active states, and alterations in energy balance. Our lab has demonstrated that immune proteins are increased in specific regions of the mouse brain that correlate with strain specific deficits. These immune proteins include toll-like receptors (Tlr), class I major histocompatibility complex proteins (MHC I), and complement proteins. There is an increasing appreciation for the role of immune proteins in neurodevelopment; however, their involvement in age-associated deficits is poorly understood. Here, we present data demonstrating that 1) activation of a specific immune receptor (Tlr2) leads to changes …