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Functions Of Fibroblast Growth Factor Homologous Factor 2 In Excitable Tissues, Christopher Marra
Functions Of Fibroblast Growth Factor Homologous Factor 2 In Excitable Tissues, Christopher Marra
Dissertations, Theses, and Capstone Projects
Purpose: Fibroblast Growth Factor Homologous Factors (FHFs) are a group of proteins known to associate with and modulate voltage-gated sodium channels (Nav) in excitable cells. The four FHF genes are differentially expressed in specific cell-types, with FHF2 expressed prominently in the hippocampus, cerebral cortex, heart and dorsal root ganglia. Due to previous unavailability of an Fhf2 knockout mouse, this gene’s functions have been understudied in comparison to other those encoding other FHFs. The purpose of this research has been to better understand the normal physiological functions of FHF2 at the cellular and system levels in the heart, sensory …