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The Cortico-Motoneuronal System In The Plexina1 Knock-Out Mouse: Sculpting The Motor Response And Activity-Dependent Plasticity, John Kalambogias

Dissertations, Theses, and Capstone Projects

Higher primates, apes, and humans have cortico-motoneuronal (CM) connections between the motor cortical areas and spinal motoneurons. The CM system is thought to confer individuated finger movements and other aspects of skilled movement control; in part, by the selective CM cell they recruit, leading to fractionated patterns of muscle activity. Although CM connections have been examined using several approaches in monkeys, the presence and properties of the CM connection was elucidated in all the species using the technique of stimulus-triggered averaging (StTA). The electrophysiological signature for the CM response is short-latency EMG facilitation (post-stimulus facilitation; PStF) in individual muscles, followed …