Open Access. Powered by Scholars. Published by Universities.®
![Digital Commons Network](http://assets.bepress.com/20200205/img/dcn/DCsunburst.png)
Neuroscience and Neurobiology Commons™
Open Access. Powered by Scholars. Published by Universities.®
- Discipline
-
- Medicine and Health Sciences (5)
- Other Neuroscience and Neurobiology (4)
- Cognitive Neuroscience (3)
- Social and Behavioral Sciences (3)
- Cell and Developmental Biology (2)
-
- Diseases (2)
- Experimental Analysis of Behavior (2)
- Genetics and Genomics (2)
- Psychology (2)
- Animal Studies (1)
- Biochemistry, Biophysics, and Structural Biology (1)
- Biological Psychology (1)
- Biology (1)
- Cancer Biology (1)
- Cognition and Perception (1)
- Computational Neuroscience (1)
- Developmental Biology (1)
- Genomics (1)
- Laboratory and Basic Science Research (1)
- Microbiology (1)
- Molecular Biology (1)
- Molecular and Cellular Neuroscience (1)
- Nervous System Diseases (1)
- Organisms (1)
- Other Psychology (1)
- Systems Neuroscience (1)
- Translational Medical Research (1)
- Virus Diseases (1)
- Keyword
-
- Aggression (1)
- Animals (1)
- Antisocial personality disorder (1)
- Astrocyte (1)
- Bayesian modeling (1)
-
- Biology (1)
- Bortezomib (1)
- CIPN (1)
- Cancer (1)
- Change detection (1)
- Chemotherapy (1)
- Chemotherapy-induced peripheral neuropathy (1)
- Chromosome Mapping (1)
- DNA (1)
- Decision making (1)
- Drosophila melanogaster (1)
- Electrophysiology (1)
- Essential (1)
- Ethyl Methanesulfonate (1)
- Female (1)
- Fusion (1)
- Genes (1)
- Genes, Essential (1)
- Genes, Insect (1)
- Glioblastoma (1)
- Individual differences (1)
- Insect (1)
- Male (1)
- Memory limitations (1)
- Molecular Sequence Data (1)
- Publication Type
Articles 1 - 7 of 7
Full-Text Articles in Neuroscience and Neurobiology
Change Detection In Rhesus Monkeys And Humans, Deepna T. Devkar, Deepna T. Devkar
Change Detection In Rhesus Monkeys And Humans, Deepna T. Devkar, Deepna T. Devkar
Dissertations & Theses (Open Access)
Visual working memory (VWM) is the temporary retention of visual information and a key component of cognitive processing. The classical paradigm for studying VWM and its encoding limitations has been change detection. Early work focused on how many items could be stored in VWM, leading to the popular theory that humans could remember no more than 4±1 items. More recently, proposals have suggested that VWM is a noisy, continuous resource distributed across virtually all items in the visual field, resulting in diminished memory quality rather than limited quantity. This debate about the nature of VWM has predominantly been studied with …
Sustained Adrenergic Signaling Promotes Cervical Cancer Progression, Nouara C. Sadaoui
Sustained Adrenergic Signaling Promotes Cervical Cancer Progression, Nouara C. Sadaoui
Dissertations & Theses (Open Access)
Background: Chronic stress and sustained adrenergic signaling are known to promote tumor progression. The underlying mechanisms behind this process are not well understood. We examined the effects of sustained adrenergic signaling on cervical cancer progression through increased expression of HPV oncogenes, E6 and E7.
Materials and Methods: ADRβ expression levels were examined in patient-derived cervical cancer samples. We used an orthotopic model of cervical cancer to investigate the effects of restraint stress on tumor growth and metastasis. We evaluated the in vivo effects of a β-blocker, propranolol, and HPV E6/E7 siRNA. In vitro, ADRβ positive cervical cancer cells were …
Effects Of Oxytocin On Human Aggression, Joseph L. Alcorn Iii
Effects Of Oxytocin On Human Aggression, Joseph L. Alcorn Iii
Dissertations & Theses (Open Access)
EFFECTS OF OXYTOCIN ON HUMAN AGGRESSION
Joseph Louis Alcorn III, B.S.
Advisory Professor: Scott D. Lane, Ph.D.
Human interaction is comprised of common, yet complex, behaviors and the outcomes of these social behaviors can beneficially or detrimentally impact individual and public health. One social behavior that can have profound detrimental outcomes is aggression. Aggression is a class of social behavior that is particularly prevalent in individuals with antisocial personality disorder (ASPD) and comorbid substance use disorder (SUD). Aggression in these individuals can manifest at maladaptive levels that place considerable burdens on public health and communities. Therefore, understanding the neurobehavioral underpinnings …
Large-Scale Identification Of Chemically Induced Mutations In Drosophila Melanogaster., Nele A Haelterman, Lichun Jiang, Yumei Li, Vafa Bayat, Hector Sandoval, Berrak Ugur, Kai Li Tan, Ke Zhang, Danqing Bei, Bo Xiong, Wu-Lin Charng, Theodore Busby, Adeel Jawaid, Gabriela David, Manish Jaiswal, Koen J T Venken, Shinya Yamamoto, Rui Chen, Hugo J Bellen
Large-Scale Identification Of Chemically Induced Mutations In Drosophila Melanogaster., Nele A Haelterman, Lichun Jiang, Yumei Li, Vafa Bayat, Hector Sandoval, Berrak Ugur, Kai Li Tan, Ke Zhang, Danqing Bei, Bo Xiong, Wu-Lin Charng, Theodore Busby, Adeel Jawaid, Gabriela David, Manish Jaiswal, Koen J T Venken, Shinya Yamamoto, Rui Chen, Hugo J Bellen
Faculty Publications
Forward genetic screens using chemical mutagens have been successful in defining the function of thousands of genes in eukaryotic model organisms. The main drawback of this strategy is the time-consuming identification of the molecular lesions causative of the phenotypes of interest. With whole-genome sequencing (WGS), it is now possible to sequence hundreds of strains, but determining which mutations are causative among thousands of polymorphisms remains challenging. We have sequenced 394 mutant strains, generated in a chemical mutagenesis screen, for essential genes on the Drosophila X chromosome and describe strategies to reduce the number of candidate mutations from an average of …
Mechanisms Of Astrocyte Contribution To Bortezomib-Induced Peripheral Neuropathy, Caleb R. Robinson
Mechanisms Of Astrocyte Contribution To Bortezomib-Induced Peripheral Neuropathy, Caleb R. Robinson
Dissertations & Theses (Open Access)
Bortezomib is a proteasome inhibitor used in the treatment of multiple myeloma and other non-solid malignancies, alone or in combination with other chemotherapy drugs. Like other chemotherapeutic agents, bortezomib treatment is frequently accompanied by chemotherapy-induced peripheral neuropathy (CIPN) that may be dose-limiting, adversely affecting quality of life and prognosis. The mechanisms behind bortezomib-induced peripheral neuropathy (BIPN) and CIPN overall are largely unknown. Recent findings in other pain models have indicated substantial involvement of glial cells in chronic pain. Although injury models have shown activation of both astrocytes and microglia following insult, research in other CIPN models has shown astrocytic activation …
Discovery And Elucidation Of The Fgfr3-Tacc3 Recurrent Fusion In Glioblastoma, Brittany C. Parker Kerrigan
Discovery And Elucidation Of The Fgfr3-Tacc3 Recurrent Fusion In Glioblastoma, Brittany C. Parker Kerrigan
Dissertations & Theses (Open Access)
Fusion genes occur due to chromosomal instability where two previously separate genes rearrange and fuse together, forming a hybrid gene. The first fusions were reported in leukemias; however, with the advent of more powerful sequencing technologies, fusions have recently been reported in several solid tumors. Using next-generation deep sequencing approaches, we discovered a fusion gene connecting the fibroblast growth factor receptor 3 (FGFR3) gene to the transforming coiled-coil containing protein 3 (TACC3) gene in glioblastoma multiforme. The fusion occurred in 8.3% of patient samples, but not in low grade or normal samples. FGFR3-TACC3 produced an in-frame …
Effects Of Resting State On Perceptual Learning, Sarah Eagleman Ph.D.
Effects Of Resting State On Perceptual Learning, Sarah Eagleman Ph.D.
Dissertations & Theses (Open Access)
Psychophysical experiments in humans have demonstrated that improvements in perceptual learning tasks occur following daytime rests. The neural correlates of how rest influences subsequent sensory processing during these tasks remain unclear. One possible neural mechanism that may underlie this behavioral improvement is reactivation. Previously evoked network activity reoccurs – reactivates - in the absence of further stimulation. Reactivation was initially discovered in the hippocampus but has now been found in several brain areas including cortex. This phenomenon has been implicated as a general mechanism by which neural networks learn and store sensory information. However, whether reactivation occurs in areas relevant …