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Full-Text Articles in Neuroscience and Neurobiology
Levels Of Parp1-Immunoreactivity In The Human Brain In Major Depressive Disorder, Aamir Shaikh
Levels Of Parp1-Immunoreactivity In The Human Brain In Major Depressive Disorder, Aamir Shaikh
Undergraduate Honors Theses
MDD is a severe and debilitating disorder that is associated with a growing global economic burden due to reduced workplace productivity along with increased healthcare resource utilization. Furthermore, depression markedly enhances the risk for suicide, mortality that is especially worrisome given that 30% of depressed individuals have an inadequate response to current antidepressants. This inadequacy of antidepressants necessitates the discovery of a better understanding of the pathobiology of MDD. Most current antidepressants work through monoamine neurotransmitters, and their relative efficacy in depression led to the now dated monoamine-deficiency hypothesis. The limited usefulness of antidepressants has led to a reinvigorated search …
Effects Of Non-Photic Zeitgebers On The Circadian Clock In The Common House Spider, Parasteatoda Tepidariorum (Araneae: Theridiidae), Mattea Garmany, Darrell Moore, Thomas C. Jones
Effects Of Non-Photic Zeitgebers On The Circadian Clock In The Common House Spider, Parasteatoda Tepidariorum (Araneae: Theridiidae), Mattea Garmany, Darrell Moore, Thomas C. Jones
Undergraduate Honors Theses
Circadian rhythms are endogenous cycles that control physiological and behavioral changes that can be affected by environmental factors which allow most eukaryotic organisms to synchronize their daily activities with the 24-hour day. Parasteatoda tepidariorum,the common house spider, demonstrates a short-period circadian clock averaging 21.6 hours when left in constant darkness, yet they are able to entrain to a 24-hour light cycle. We tested whether these spiders were able to use non-photic Zeitgebers to entrain to the 24-hour day. Periodic presentation of food and disturbance were not found to be effective cues for the spiders’ entrainment. A few individuals were clearly …