Neuroscience and Neurobiology Commons^™

Effects Of Transcranial Direct Current Stimulation On Metamemory Vary By Task Difficulty, Tiffanie T. Li

Dissertations, Theses, and Capstone Projects

Metamemory is broadly defined as the awareness of one’s memory and consists, in part, of a process referred to as monitoring, where one is assessing the contents of their memory. Feeling of knowing (FOK) is one metamemory monitoring judgment where one rates how strongly they believe they will remember a currently unrecalled item. Prior work has shown that HighDefinition Transcranial Direct Current Stimulation (HD-tDCS) over the dorsal lateral prefrontal cortex (DLPFC) led to greater metamemory accuracy and that HD-tDCS over the anterior temporal lobe (ATL) led to better recall for medium difficulty questions. Other work has also shown that effects …

Multilingualism And Memory: Investigating Possible Differences In The Abilities Of Monolingual And Multilingual College Students, Clara E. Barned

Honors Projects

This study investigated whether there is a difference in the memories of monolingual and multilingual undergraduate students using simple memorization tasks. There were 46 participants, 30 of which were monolingual (only knew one language) and 16 of which were multilingual (knew two or more languages). There was found to be no significant difference between the performance of the two groups, with the data generating a p-value of 0.557. This study further suggests related avenues of research and ways in which the study could be improved in the future.

Assessing The Impact Of Lipopolysaccharide On Learning And Memory In Rats, Anahat Luthra

Undergraduate Student Research Internships Conference

The immune system and the central nervous system (CNS) have a bi-direction relationship, modulating one another.⁴ Proinflammatory cytokines released from CNS immune cells have an impact on cognitive processes such as learning and memory.¹ Liposaccharide (LPS), a cell wall component of Gram-negative bacteria, which is used to activate proinflammatory cytokine release has been found to impact learning and memory processes, such as in the anticipatory nausea paradigm (ANP).² Anticipatory nausea and vomiting is that which may occur before a chemotherapy treatment session begins in a patient who has had chemotherapy before. It is caused by triggers like …

The Effects Of Floral Attributes And Conspecifics On Bumble Bee Forager Memory, Lucas Lauter, Tiffany Dinh

Undergraduate Research Symposium

What do bees remember about flowers? These memories are important for both bees and flowers. The bees have better foraging success and gain more nectar and pollen from flowers when they remember the most rewarding flower types. More memorable flowers will be visited more frequently, resulting in more successful pollination for the plant. At the same time, bees can also learn about flowers from other bees and may remember this information differently. We are training and testing three floral cues and a single social cue to see how the different types of cues affect their learning and memory of rewarding …

Effects Of Music Exposure On Autobiographical Memory In Alzheimer's Patients: A Systematic Review And Meta-Analysis, Gregory Vance

Honors Theses

The progression of Alzheimer’s disease is primarily characterized by a loss of memory concerning past events, as well as a lack in ability to create new memories. While this spans across many subsets of memory, such as recognition, recall, and autobiographical memory, there seems to be a lesser impact on musical memory in those with Alzheimer’s. Multiple studies have suggested that exposure to music and introduction of music therapy can even improve other aspects of memory in Alzheimer’s patients. This systematic review and meta-analysis sought to examine the relationship between music exposure and autobiographical memory specifically. A pool of electronic …

Flashbulb Memories Among College Students During Covid-19, Sabah Qureshi

Honors Undergraduate Theses

Flashbulb memories are formed through widely shared events that have affected the culture and community. The “flash” in flashbulb memories refers to the specific details that individuals have developed in their memories. The presented research focuses on the specific event of college students at the University of Central Florida (UCF) hearing about university closure due to the COVID-19 pandemic. This research study sought to identify the variables that have affected the accuracy of flashbulb memories formation regarding the event of college students hearing about university closure because of the pandemic. The variables of the students’ relevance to the university, location, …

Neural Correlates And Neuroanatomy Of Juvenile And Adult Contextual Fear Memory Retention, Natalie Odynocki

Legacy Theses & Dissertations (2009 - 2024)

AbstractFear is an evolutionarily conserved mechanism that allows an organism to discern potential harm and act accordingly by engaging in defensive behaviors. While fear is an adaptive response, dysregulation of fear by means of a traumatic event can lead to psychiatric conditions such as post-traumatic stress disorder (PTSD). Animal research using rodents in Pavlovian context fear conditioning experiments allows for the ability to study the underlying neural circuitry of threat-appropriate and aberrant fear learning and memory that may contribute to PTSD. However, despite reports that women are more than two times more likely to develop PTSD compared to men, the …

The Giver: Vision & Memory, Alexander J. Dontre

All Faculty and Staff Scholarship

A memory hole is the banishment of problematic thoughts. We exile that which we prefer not to exist. Enter the perilous Memory Hole: The Psychology of Dystopia, to explore a legion of social and psychological themes through the lens of dystopian literature. The crushing fist of 1984 annihilating thoughts from existence as a means of persuasion. The exquisite seduction of addiction as an agent of control in Brave New World. Incineration of the written word to bask in the embers of peace of mind in Fahrenheit 451. Each chapter weaves in and out of the dystopian realms forged …

Memoir Dataset: Quantifying Image Memorability In Adolescents, Gal Almog, Yalda Mohsenzadeh

Undergraduate Student Research Internships Conference

Every day, humans observe and interact with hundreds of images and scenes; whether it be on a cellphone, on television, or in print. Yet a vast majority of these images are forgotten, some immediately and some after variable lengths of time. Memorability is indeed a property intrinsic to all images that can be extracted, as well as predicted. While memory itself is a process that occurs in the brain of an individual, the concept of memorability is an intrinsic, continuous property of a stimulus that can be both measured and manipulated. We selected images from the MemCat data set that …

Exercise, Cognition, And Cannabis Use In Adolescents, Ileana Pacheco-Colón

FIU Electronic Theses and Dissertations

Heavy and/or chronic cannabis use has been associated with neurocognitive impairment and decline, often in domains such as memory and executive functioning. On the other hand, exercise has been linked to positive effects on brain and cognitive health across the lifespan, as well as to better substance use outcomes. Despite this, little is known about the ways in which exercise could help prevent or ameliorate adverse cannabis-related outcomes among adolescents.

Through three separate studies, the current dissertation examines interrelations among exercise, cognition, and cannabis use in children and adolescents in an effort to determine whether exercise can prevent or ameliorate …

Behavioral, Physiological, And Molecular Characterization Of Long-Term Administration Of A Novel Estrogen Receptor Beta Agonist In A Mouse Model Of Menopause, Aaron William Fleischer

Theses and Dissertations

The menopausal loss of circulating hormones, including estrogens, is associated with negative symptoms, such as hot flashes, anxiety and depression, cognitive decline, and weight gain. Although estrogenic hormone therapies (HT) prevent many of the negative symptoms related to the menopausal transition, these same therapies are associated with increased health risks, such as the development of breast and ovarian cancers, which is mediated by the activation of the a (ERa), but not b (ERb), estrogen receptor isoform. Furthermore, ERb agonism has previously been shown to reduce preclinical indices of hot flashes, memory decline, anxiety, and depression. As most ERb agonists are …

Long-Term Memory For Associative Conditioning And Glutamate Receptor Expression, Kaitlyn Dybing, Waleed Faruqi, Janie Aguilera, Roma Zakos, Lina Dahlberg, Jacqueline K. Rose

WWU Honors College Senior Projects

This poster demonstrates the unique methodology used in Dr. Jacqueline Rose's lab at Western Washington University to study the impact of glutamate receptors on long-term memory in C. elegans. The poster includes a description of the purpose of the study, reasons for use of C. elegans, the methods used, as well as the data and interpretation of the results.

An Eeg Study On Loneliness And Recognition Memory, Carmen Jia Wen Chek

Electronic Theses and Dissertations

Loneliness, the perception of unmet social needs, has been shown to relate to recollection-based recognition deficits, but the relationship between loneliness and recognition memory (i.e., recollection and familiarity) has not been thoroughly examined. The current study hypothesized that more lonely individuals would have lower recognition memory performance, specifically recollection, with smaller ERP parietal old-new effects than less lonely individuals. Forty participants, grouped into less (n = 13) and more (n = 9) lonely groups based on their R-UCLA responses, completed an associative memory task. EEG was used to assess recognition memory effects. Results showed no significant difference in …

Attention Capture By Episodic Long-Term Memories: Evidence From Eye Movement Data, Allison Eleanor Nickel

Theses and Dissertations

Successfully navigating the world on a moment-to-moment basis requires the interaction of multiple cognitive processes. Therefore, studies that examine when and how these fundamental processes interact can provide important insights into how we behave. Many studies indicate that long-term memory can facilitate search for a target object (e.g., contextual cueing), however, the ways in which long-term memory might capture attention and disrupt goal-directed behavior have not been well studied. In five experiments, questions about whether encoded objects might capture attention, even when they are task-irrelevant, were addressed. Each experiment began with an encoding phase, where participants were instructed to commit …

What Makes An Image Memorable? Effects Of Encoding On The Mechanism Of Recognition, Asiya Gul

Theses and Dissertations (Comprehensive)

Memory is undoubtedly one of the most important processes of human cognition. A long line of research suggests that recognition relies on the assessment of two explicit memory phenomena: familiarity and recollection. Researchers who support the Dual Process Signal Detection (DPSD) model of recognition memory link the FN400 component (a negative ERP deflection peaking around 400 ms at frontal electrodes) with familiarity; however, it is currently unclear whether the FN400 reflects familiarity or implicit memory. Three event-related potentials (ERP) studies were conducted to determine whether implicit memory plays a role in setting up encoding strategies, and how these encoding strategies …

The Influence Of Neural Reward Processing On Memory In Depression, Nathan M. Hager

Psychology Theses & Dissertations

Theories and research suggest that depression involves impaired reward sensitivity and a deficit in memory for rewarding stimuli. Some researchers propose that this memory deficit may result from reduced neural reward sensitivity, which impairs the encoding of reward-related memories, but few studies have directly probed this connection. Such research may benefit from examining the reward positivity (RewP), an event-related potential (ERP) previously linked to reduced reward sensitivity in depression. Undergraduates with high or low self-reported depression completed a task in which they chose one of three doors, revealing a neutral word written in a color which indicated an outcome of …

Isolating Item And Subject Contributions To The Subsequent Memory Effect, Jihyun Cha

Arts & Sciences Electronic Theses and Dissertations

The subsequent memory effect (SME) refers to the greater brain activation during encoding of subsequently recognized items compared to subsequently forgotten items. Previous literature regarding SME has been primarily focused on identifying the role of specific regions during encoding or factors that potentially modulate the phenomenon. The current dissertation examines the degree to which this phenomenon can be explained by item selection effects; that is, the tendency of some items to be inherently more memorable than others. To estimate the potential contribution of items to SME, I provided participants a fixed set of items during encoding, which allowed me to …

Domestication And Cognitive Complexity, David R. Brodbeck, Madeleine I. R. Brodbeck, Keeghan Rosso

Animal Sentience

Marino and Merskin (2019) list a number of tasks that sheep can perform well. As comparative psychologists, we are not surprised by these results. Indeed, many domesticated animal species show similar abilities.

The Relationship Between Cognitive And Neural Bases Of Metamemory Judgments, Alexandra M. Gaynor

Dissertations, Theses, and Capstone Projects

Metamemory monitoring, the process of making subjective assessments of the status of one’s own memory, is crucial to guiding behavior and effective learning. Past cognitive research has shown that subjective confidence judgments are inferential in nature, and based on cues available at the time of the judgment. When confidence is based on cues that are related to objective memory performance, metamemory accuracy is high. However, past studies have shown that metamemory monitoring tends to be inaccurate because individuals base their confidence on information that is not predictive of memory success, such as the fluency with which items were encoded during …

Neural Correlates Of Memory Decisions Made In The Face Of Conflict, Elaine Mahoney

Theses and Dissertations

We’ve all experienced moments where, for some reason or another, we don’t want to reveal to others what we truly know. The current experiment investigated questions about the behavioral and neural correlates of these types of memory decisions made in the face of a conflicting goal. Participants in this experiment studied several scene-face pairs and were tested with three-face displays preceded by studied scene cues. They were instructed to indicate whether the three-face display contained the matching associate or not. Critically, half of the participants were instructed to simulate feigned memory impairment (i.e. simulators), while the remainder were instructed to …

Moderate Prenatal Alcohol Exposure Impairs Performance In An Object-Place-Paired-Associate Task, Lilliana May Sanchez

Psychology ETDs

Memory impairments, including spatial and object processing, are often observed in individuals with Fetal Alcohol Spectrum Disorder. Much attention has been directed towards the hippocampus, which displays significant alterations after moderate prenatal alcohol exposure (PAE). In the present study, we tested a moderate PAE rat model in an object-place-paired-associate (OPPA) task, previously shown to require hippocampal processing. The OPPA task was composed of training rats to discriminate between an identical pair of objects presented in 180° opposite arms of a radial arm maze. Animals were given a total of 10 trials per day over 14 consecutive days of training and …

Assessing The Long-Term Sequelae Of Mild Traumatic Brain Injury, Janna Mantua

Doctoral Dissertations

A mild traumatic brain injury (mTBI), also known as a concussion, is defined as an injury that results in an alteration of consciousness or mental status. Previous studies have shown mTBI populations experience a number of chronic (> 1 year) symptoms, such as sleep disturbances (e.g., sleep stage alterations), mood alterations (e.g., depressive symptoms), and cognitive alterations (e.g., poor concentration). The three chapters of this dissertation sought to explore these long-term sequelae and the possible interrelations between them. In the first experiment, sleep-dependent memory consolidation of neutral stimuli was probed in a chronic mTBI sample and a control, uninjured sample. …

Rescuing Age-Related Proteolysis Deficits With Methylene Blue, Shane E. Pullins

Theses and Dissertations

The average lifespan is constantly increasing with the advent of new medical techniques, and age-related cognitive decline is becoming a prevalent societal issue. Even during healthy aging, humans and rats exhibit progressive deficits in episodic/declarative memory. In laboratory rats, age-related memory impairment can be assessed with trace fear conditioning (TFC). Recent research implicates ubiquitin proteasome system-mediated protein degradation in the synaptic plasticity supporting memory formation and retrieval. In rats, aging leads to decreased basal proteolytic activity in brain structures known to support the acquisition and retrieval of trace fear memories, and our preliminary data suggests activity-dependent proteasome activity declines in …

The Impact Of Delay On Retrieval Success In The Parietal Memory Network, Nathan Anderson

Arts & Sciences Electronic Theses and Dissertations

Recent work has identified a Parietal Memory Network (PMN), which exhibits regular patterns of activation during memory encoding and retrieval. Among these characteristic patterns, this network displays a strong “retrieval success” effect, showing greater activation for correctlyremembered studied items (hits) compared to correctly-rejected novel items (CRs). To date, most relevant studies have used short retention intervals. Here, we ask if the retrieval success effect seen in the PMN would remain consistent over a delay. Twenty participants underwent fMRI while encoding and recognizing scenes. Greater activity for hits than for correctly-rejected lures within PMN regions was observed after a short delay …

Combined Mnemonic Strategy Training And High-Definition Transcranial Direct Current Stimulation For Memory Deficits In Mild Cognitive Impairment, Benjamin M. Hampstead, Krishnankutty Sathian, Marom Bikson, Anthony Y. Stringer

Publications and Research

Introduction: Memory deficits characterize Alzheimer’s dementia and the clinical precursor stage known as mild cognitive impairment. Nonpharmacologic interventions hold promise for enhancing functioning in these patients, potentially delaying functional impairment that denotes transition to dementia. Previous findings revealed that mnemonic strategy training (MST) enhances long-term retention of trained stimuli and is accompanied by increased blood oxygen level–dependent signal in the lateral frontal and parietal cortices as well as in the hippocampus. The present study was designed to enhance MST generalization, and the range of patients who benefit, via concurrent delivery of transcranial direct current stimulation (tDCS).

Methods: This protocol describes …

A Behavioral And Neuroimmune System Model Of The Effects Of Chronic Low-Level Lead Exposure In Young Male C57bl/6j Mice, Mayra Gisel Flores-Montoya

Open Access Theses & Dissertations

Chronic low-level lead exposure reduces memory in children however the brain mechanisms mediating these effects are not known. In previous studies we showed that early lead exposure reduced olfactory memory and exploratory behavior in young mice, and reduced microglia cell density in hippocampus/dentate gyrus. The present studies aimed to identify additional behavioral tests that were sensitive to early low-level lead exposure in young mice; and to examine whether microglia upregulated factors known to promote cell migration. Seventy-two C57BL/6J male mice were exposed to 0 ppm (controls), 30 ppm (low-dose), or 430 ppm (high-dose) of lead acetate via dams' milk from …

Learning, Memory, Cognition, And The Question Of Sentience In Fish, Robert Gerlai

Animal Sentience

Evolutionarily conserved features have been demonstrated at many levels of biological organization across a variety of species. Evolutionary conservation may apply to complex behavioral phenomena too. It is thus not inconceivable that a form of sentience does exist even in the lowest order vertebrate taxon, the teleosts. How similar it is to human sentience in its level of complexity or in its multidimensional features is a difficult question, especially from an experimental standpoint, given that even the definition of human sentience is debated. Woodruff attempts a Turing-like test of fish sentience, and lists numerous neuroanatomic, neurophysiological and behavioral similarities between …

Protein Kinase Mzeta (Pkm-Ζ) Regulates Kv1.2 Dependent Cerebellar Eyeblink Classical Conditioning, Kutibh Chihabi

Graduate College Dissertations and Theses

Learning and memory has been a topic that has captured the attention of the scientific and public communities since the dawn of scientific discovery. Without the faculty of memory, mammals cannot experience nor function in the world; among homosapiens specifically, language, relationships, and personal identity cannot be developed (Eysenck, 2012). After all, some philosophers such as John Locke argued we are nothing but a collection of past memories in which we have developed and improved upon (Nimbalkar, 2011).

Understanding the cellular mechanisms behind learning, and the subsequent formation of memory, has been a topic that has garnered scientific interest for …

Perceiving Oldness In Parietal Cortex: Fmri Characterization Of A Parietal Memory Network, Adrian Gilmore

Arts & Sciences Electronic Theses and Dissertations

The manner in which the human brain recognizes certain stimuli as novel or familiar is a matter of ongoing investigation. The overarching goal of this dissertation is to improve our understanding of how this may be accomplished. More specifically, work contained herein focuses on a recently described "parietal memory network" (PMN; Gilmore et al., 2015) that shows opposite patterns of activity when perceiving novel or familiar stimuli: deactivating in response to novelty, and activating in response to familiarity. Critically, our understanding of this network is based on explicit memory tasks, in which subjects are deliberately instructed to learn or remember …

The Mechanisms Underlying Cocaine-Induced Overexpression Of Basic Fibroblast Growth Factor (Bfgf, Fgf2), An Effect Reversed By Extinction, Madalyn Hafenbreidel

Theses and Dissertations

Drug addiction is characterized by compulsive drug use and chronic relapse despite negative consequences. Drug-induced structural and functional changes in the brain are thought to underlie these characteristics. One mechanism that may mediate these characteristics are growth factors, such as basic fibroblast growth factor (bFGF or FGF2), as they are necessary for cellular growth, survival, differentiation, and have roles in memory, mood, and anxiety disorders. bFGF mRNA and protein expression is increased following stimulant administration and is necessary for stimulant-induced changes in dendrites and behavioral sensitization. Moreover, addiction is maintained by cues associated with the drug, as they can can …