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Full-Text Articles in Neuroscience and Neurobiology

Associations Between Hypothalamic-Pituitary-Adrenal Axis System Gene Variants And Cortisol Reactivity In Preschoolers: Main Effects And Gene-Environment Interactions, Haroon I. Sheikh Jun 2014

Associations Between Hypothalamic-Pituitary-Adrenal Axis System Gene Variants And Cortisol Reactivity In Preschoolers: Main Effects And Gene-Environment Interactions, Haroon I. Sheikh

Electronic Thesis and Dissertation Repository

Exposure to stressful events during early development has consistently been shown to produce long lasting effects on the hypothalamic-pituitary-adrenal (HPA) axis, which may increase vulnerability to mood and anxiety disorders. Recently reported genetic association studies indicate that these disorders may be influenced, in part, by gene-environment interactions (GxE) involving polymorphisms within the corticotrophin-releasing hormone and monoaminergic system genes. However, little is known about how genetic variants and life stress work to shape children’s neuroendocrine reactivity and emerging symptoms. Therefore, the aim of this thesis is to examine main effects of candidate genes and GxE on the neuroendocrine stress response and …


Where Do I Know That? A Distributed Multimodal Model Of Semantic Knowledge, Kevin M. Stubbs Apr 2014

Where Do I Know That? A Distributed Multimodal Model Of Semantic Knowledge, Kevin M. Stubbs

Undergraduate Honors Theses

As computers have grown more and more powerful, computational modeling has become an increasingly valuable tool for evaluating real world findings. Likewise, brain imaging has become increasingly powerful as is evidenced by recent fMRI findings which support the exciting possibility that semantic memory is segregated by modality in the brain (Goldberg et al., 2006b). The present study utilizes connectionist modeling to put the distributed multi-modal framework of semantic memory to the test, and represents the next step forward in the line of sensory-functional models. This model, based around the McRae et al. (2005) feature production norms, includes individual implementations of …