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Full-Text Articles in Neuroscience and Neurobiology

The Incorporation Of Indigenous Tradition In Psychedelic-Assisted Psychotherapy: A Pathway To Cultural Inclusivity Within Mental Health, Angelo Adonnis Winings Jan 2021

The Incorporation Of Indigenous Tradition In Psychedelic-Assisted Psychotherapy: A Pathway To Cultural Inclusivity Within Mental Health, Angelo Adonnis Winings

Senior Projects Spring 2021

The use of psychedelic medicine has been a part of society and the evolution of humanity since the beginning of our existence. Throughout the years, these practices were integrated into cultures around the world throughout the years, as societal structures promoted traditional practices reflective of ritual and custom. One such practice that survived the test of time is the use of psychoactive substances to promote mental states that put the user in touch with spiritual ancestors as well as with the subtleties of the world around them. These practices included tribal usage in indigenous cultures from Africa, the Americas, parts …


Phonophobia Mediates The Relationship Between The Myelinated Vagus And Selective Mutism, Alexandra Sherwood Batzdorf Jan 2016

Phonophobia Mediates The Relationship Between The Myelinated Vagus And Selective Mutism, Alexandra Sherwood Batzdorf

Senior Projects Spring 2016

When active, the myelinated vagus (the tenth cranial nerve) acts as a brake that inhibits sympathetic activity by reducing heart rate and blood pressure, and thus allows for social engagement by redirecting metabolic resources. Among those with selective mutism (SM), a disorder characterized by an inability to speak in certain situations, the vagal brake is dysregulated. One consequence of this is a weakening of the middle-ear acoustic reflex (MEAR), which helps clarify human voices and filters out low-frequency background noise, including the speaker’s own voice. I tested a proposed etiological model of SM and comorbid social anxiety disorder (SAD) by …


Effects Of Early Life Stress On Anhedonia And Striatal Dopamine Concentration Depends On Variation In Catechol-O-Methyltransferase (Comt) Genotype, Sally Lauren Cole Jan 2016

Effects Of Early Life Stress On Anhedonia And Striatal Dopamine Concentration Depends On Variation In Catechol-O-Methyltransferase (Comt) Genotype, Sally Lauren Cole

Senior Projects Spring 2016

Depression is a serious, costly, and heterogeneous disorder for which no one genetic determinant has been identified. Research has shown that stress, and subsequent hypothalamic-pituitary-adrenal (HPA) axis dysregulation, is a significant predictor of depression, and one particular stressor that has been linked to vulnerability to depression and HPA axis dysregulation is early life trauma. Due to the heterogeneity and complexity of depression, it is likely that specific gene-environment interactions play a role in the development of depression. Interaction between catechol-O-methyltransferase (COMT) Val158Met variants with specific environmental factors can potentially increase vulnerability to depression. The present proposed experiment …


Effects Of Acute Nicotine On Larval Zebrafish Exploratory Behavior In A Complex Environment, Brandon Chen Jan 2015

Effects Of Acute Nicotine On Larval Zebrafish Exploratory Behavior In A Complex Environment, Brandon Chen

Senior Projects Spring 2015

The larval zebrafish is emerging as a useful model to assess neurobehavioral toxicity. A variety of behavioral assays have been developed to characterize normal behavior and the acute and chronic effects of a variety of compounds. To date, such behavioral assays have been limited to relatively simple behavioral measures (e.g., swimming activity in a single well). The present experiment describes methodology to assess exploratory behavior in 5 days-post-fertilization (5 dpf) larval zebrafish using a six-chamber, complex well-plate. In addition, the effect of acute nicotine exposure on exploratory activity in this complex environment was examined. Five dpf TU strain larvae were …