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Articles 1 - 6 of 6
Full-Text Articles in Neuroscience and Neurobiology
The Relationship Between Cognitive Impairment In Psychiatric Patients And Readmission Rate To An Inpatient Facility, Cherilyn Isis Schuff
The Relationship Between Cognitive Impairment In Psychiatric Patients And Readmission Rate To An Inpatient Facility, Cherilyn Isis Schuff
Theses and Dissertations
The primary intention of this study was to further understand the impact of assessing cognitive impairment in psychiatric patients, as a mediating factor on readmission rates. Mild cognitive dysfunction impacts a patient’s functional outcomes (Bowie & Harvey, 2006; Davis et al., 2012; Marcantonio, et al., 2001). Little information exists to guide best practices in the treatment of adults with cognitive impairment who are hospitalized for acute conditions (Davis et al., 2012). A cognitive impairment may impact patient prognosis and ability to function outside of a setting focused on stabilization. Neuropsychological testing is a valuable tool in predicting a patient’s cognitive …
Behavioral, Physiological, And Molecular Characterization Of Long-Term Administration Of A Novel Estrogen Receptor Beta Agonist In A Mouse Model Of Menopause, Aaron William Fleischer
Behavioral, Physiological, And Molecular Characterization Of Long-Term Administration Of A Novel Estrogen Receptor Beta Agonist In A Mouse Model Of Menopause, Aaron William Fleischer
Theses and Dissertations
The menopausal loss of circulating hormones, including estrogens, is associated with negative symptoms, such as hot flashes, anxiety and depression, cognitive decline, and weight gain. Although estrogenic hormone therapies (HT) prevent many of the negative symptoms related to the menopausal transition, these same therapies are associated with increased health risks, such as the development of breast and ovarian cancers, which is mediated by the activation of the a (ERa), but not b (ERb), estrogen receptor isoform. Furthermore, ERb agonism has previously been shown to reduce preclinical indices of hot flashes, memory decline, anxiety, and depression. As most ERb agonists are …
Contextually Modulated Avoidance Behavior In Rats Post-Pavlovian Extinction, Lauren Branigan
Contextually Modulated Avoidance Behavior In Rats Post-Pavlovian Extinction, Lauren Branigan
Theses and Dissertations
The following study sought to examine the psychological substrates of renewal (e.g.., context dependent extinction processes) for conditioned avoidance behaviors in rats. Using signaled active avoidance conditioning, rats acquired two-way shuttle responding, to two different auditory stimuli. These behaviors were then extinguished through exposure to the auditory stimuli where shuttling behavior was now without consequence. Subjects were then tested for renewal of avoidance in three distinct renewal sequences (e.g., ABA vs ABB, AAB vs AAA, and ABC vs ABB) in three separate groups of rats. It was found that subjects showed more responding to a stimulus presented outside of its …
How Does Anxiety Affect Cognitive Control? Proactive And Reactive Control Under State Anxiety, Youcai Yang
How Does Anxiety Affect Cognitive Control? Proactive And Reactive Control Under State Anxiety, Youcai Yang
Theses and Dissertations
Cognitive control is a construct that prioritizes how we process stimuli and information and execute behaviors to flexibly and efficiently adapt to internal goals and external environmental changes. A recent theory, the Dual Mechanism of Control (DMC), distinguishes this phenomenon by two distinct cognitive control operations: proactive control and reactive control (Braver, 2012). Anxiety increases the allocation of attentional and working memory resources to threat-related stimuli, which impairs cognitive performance (Sarason, 1988), but additional work is needed to assess how anxiety impacts these two distinct forms of cognitive control. In this study, I examined how state anxiety affected proactive control, …
Rescuing Age-Related Proteolysis Deficits With Methylene Blue, Shane E. Pullins
Rescuing Age-Related Proteolysis Deficits With Methylene Blue, Shane E. Pullins
Theses and Dissertations
The average lifespan is constantly increasing with the advent of new medical techniques, and age-related cognitive decline is becoming a prevalent societal issue. Even during healthy aging, humans and rats exhibit progressive deficits in episodic/declarative memory. In laboratory rats, age-related memory impairment can be assessed with trace fear conditioning (TFC). Recent research implicates ubiquitin proteasome system-mediated protein degradation in the synaptic plasticity supporting memory formation and retrieval. In rats, aging leads to decreased basal proteolytic activity in brain structures known to support the acquisition and retrieval of trace fear memories, and our preliminary data suggests activity-dependent proteasome activity declines in …
Is Contextual Cue Learning Flexible? An Eye-Movement Study Of The Contextual Cueing Task, Youcai Yang
Is Contextual Cue Learning Flexible? An Eye-Movement Study Of The Contextual Cueing Task, Youcai Yang
Theses and Dissertations
Visual searching can be facilitated without awareness when the target is repeatedly presented in an invariant context in tasks such as contextual cueing (Chun & Jiang 1998). A behavioral cost (increased reaction time) was observed when the target was moved to a new location but no such cost was observed when the target returned to the initial location. The lack of cost for return suggests two possible explanations: One is that the learning can update the initial learning to acquire both target locations, which suggests the implicit learning is flexible. The other is that the contextual cue leaning cannot update …