Open Access. Powered by Scholars. Published by Universities.®
Neuroscience and Neurobiology Commons™
Open Access. Powered by Scholars. Published by Universities.®
- Keyword
-
- Aging (1)
- Alzheimer's disease (1)
- Auditory Brainstem Response (1)
- Auditory Evoked Potentials (1)
- Aβ (1)
-
- BDNF (1)
- Baroreflex sensitivity (1)
- Brain development (1)
- Cardiovagal control (1)
- Chloroquine (1)
- Continuous Loop Averaging Deconvolution (1)
- Cortical autonomic network (1)
- Familiality (1)
- Fetal growth restriction (1)
- GM3 (1)
- Gangliosides (1)
- Guinea pig (1)
- Hippocampus (1)
- Late Latency Response (1)
- Learning (1)
- Long-term endurance training (1)
- Luxol fast blue (1)
- Myelin basic protein (1)
- Myelination (1)
- NMDA (1)
- Neuroinflammation (1)
- ShcC (1)
- Stroke (1)
- Synaptogenesis (1)
- Synaptophysin (1)
Articles 1 - 5 of 5
Full-Text Articles in Neuroscience and Neurobiology
An Investigation Into The Combined Effects Of Β-Amyloid Toxicity And Cerebral Ischemia On The Pathological Expression Of Gangliosides., Jeffrey D. Hepburn
An Investigation Into The Combined Effects Of Β-Amyloid Toxicity And Cerebral Ischemia On The Pathological Expression Of Gangliosides., Jeffrey D. Hepburn
Electronic Thesis and Dissertation Repository
Identifying mechanisms underlying the synergistic pathological interaction between stroke and Alzheimer’s disease (AD) can effectively guide future therapeutic strategies for these highly co-morbid conditions. Aberrant ganglioside expression marked by the pathological accumulation of ganglioside GM3 is common to stroke and AD, yet it is unclear whether GM3 is synergistically enhanced in a comorbid model, or if GM3 is a viable therapeutic target. Adult male Wistar rats received a unilateral ischemic striatal infarct via endothelin-1 (ET-1) injection alone or in combination with bilateral intracerebroventricular injection of the β-Amyloid 25-35 peptide (Aβ) to induce generalized Aβ toxicity (Aβ/ET-1). Animals were sacrificed after …
Neuroprotective Effects Of Long-Term Endurance Training On The Cortical Autonomic Network In The Aging Brain, Torri A. Luchyshyn
Neuroprotective Effects Of Long-Term Endurance Training On The Cortical Autonomic Network In The Aging Brain, Torri A. Luchyshyn
Electronic Thesis and Dissertation Repository
This study tested whether long-term endurance training in older adults (ET; n = 15, 55 ± 4 years, relative VO2max = 50 ± 8 ml/kg/min) would alter cardiovagal control and preserve the cortical autonomic network compared to age-matched controls (CON; n = 15, 56 ± 4 years, relative VO2max = 37 ± 9 ml/kg/min). The hypothesis predicts 1) altered deactivation patterns of the ventral medial prefrontal cortex (vMPFC) in response to isometric hand grip (IHG) and 2) greater indices of cardiovagal control; a) increased baroreflex sensitivity at rest, b) greater heart rate change (ΔHR) and c) …
Familiality Of Auditory Evoked Potentials: Preliminary Investigation Of The Auditory Brainstem Response And Late Latency Cortical Response, Matthew B. Lucas
Familiality Of Auditory Evoked Potentials: Preliminary Investigation Of The Auditory Brainstem Response And Late Latency Cortical Response, Matthew B. Lucas
Electronic Thesis and Dissertation Repository
Twenty-four participants, consisting of six sibling pairs and six non-sibling pairs, participated in this study investigating the familiality of auditory evoked potentials (AEPs). The auditory brainstem response (ABR) recorded at high stimulus rates, revealed that Wave V latency increases, while amplitude decreases as stimulus rate increases. ABR Wave V latency was also found to increase with click position within a stimulus train, plateauing by the third stimulus. No evidence for familiality was found with respect to the ABR Wave V under these conditions. The late latency response (LLR) components N1 and P2 were found to decrease between the first and …
Investigating Binding Partners Of The Neuronal Adaptor Protein Shcc Involved In Learning And Memory, Kayla Rm Driver
Investigating Binding Partners Of The Neuronal Adaptor Protein Shcc Involved In Learning And Memory, Kayla Rm Driver
Electronic Thesis and Dissertation Repository
Learning and memory are complex processes: many signaling pathways must come together to start the process of long-term potentiation (LTP), an improvement in the connection between two neurons as a result of a previous signal. LTP involves both the TrkB and NMDA receptor signaling cascades, and there is evidence to support cross-talk between TrkB and the NMDA receptor subunit NR2B using adaptor proteins. ShcC is thought to be involved in learning and memory as ShcC knockout mice have increased hippocampal LTP and better performance in Spatial Memory tasks (Miyamoto et al., 2005). Our results indicate that ShcC binds to both …
Placental Insufficiency Resulting In Fetal Growth Restriction Alters Synaptic Development And Neuronal Myelination In Guinea Pigs At Term, Karolina Piorkowska
Placental Insufficiency Resulting In Fetal Growth Restriction Alters Synaptic Development And Neuronal Myelination In Guinea Pigs At Term, Karolina Piorkowska
Electronic Thesis and Dissertation Repository
Aberrant neuronal connectivity in utero may underlie the association between fetal growth restriction (FGR) and increased risk for later cognitive disorders and encephalopathy. This study examines changes in synaptic development and myelination focussing on the hippocampus using a guinea pig model of placental insufficiency. Placental insufficiency was induced at mid-gestation by uterine artery ligation or cauterization which produced fetuses with a range of body weight and proportion at term. Synaptic markers, synaptophysin and synaptopodin, were decreased in FGR animals suggesting fewer synapses were formed and furthermore that fewer synapses matured with symmetrical growth restriction when compared to appropriate for gestational …