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Calcium Dyshomeostasis In Neurodegeneration, Nicholas Emanuel Karagas
Calcium Dyshomeostasis In Neurodegeneration, Nicholas Emanuel Karagas
Dissertations & Theses (Open Access)
Neurodegenerative diseases, despite constituting a major and growing cause of mortality globally, have few effective treatments. In order to develop novel therapeutics to combat neurodegeneration, a better understanding of the molecular mechanisms underlying these diseases is needed. Neurons rely on Ca2+ to mediate many of their unique functions, and aberrant Ca2+ signaling has been broadly implicated in neurodegeneration. The goal of this dissertation is to delineate specific examples of Ca2+ dyshomeostasis that I have uncovered in Drosophila models of neurodegeneration.
I first define the role a neurodegeneration-associated mutation plays in perturbing presynaptic [Ca2+], which is …