Neuroscience and Neurobiology Commons^™

De-Coding The Impact Of Evolved Changes In Gene Expression And Cellular Phenotype On Primate Evolution, Trisha Zintel

Doctoral Dissertations

The goal of the dissertation work outlined here was to investigate the influence of proximal processes contributing to evolutionary differences in phenotypes among primate species. There are numerous previous comparative analyses of gene expression between primate brain regions. However, primate brain tissue samples are relatively rare, and my results have contributed to the pre-existing data on more well-studied primates (i.e. humans, chimpanzees, macaques, marmosets) as well as produced information on more rarely-studied primates (i.e. patas monkey, siamang, spider monkey). Additionally, the primary visual cortex has not previously been as extensively studied at the level of gene expression as other brain …

The Dysregulation Of Circadian Rhythms And Its Relation To Hippocampal Neurodegenerative Disease, John Patrick Mccauley

Legacy Theses & Dissertations (2009 - 2024)

Circadian rhythms modulate body temperature, sleep-wake cycles and cognitive functions like learning and memory. Interestingly, patients suffering from neurodegenerative disease like Alzheimer’s disease and brain insults like traumatic brain injury experience dysregulated circadian rhythms and learning and memory deficiencies as a symptom. The core molecular machinery that establishes these rhythms relies on the activation of positive and negative transcriptional-translational feedback loops within the hypothalamic suprachiasmatic nucleus (SCN). Subordinate circadian oscillators distributed throughout the peripheral and central nervous system follow the rhythmic activity of the SCN. One of these, the hippocampus, is mostly involved in regulating memory formation and recall. Experimental …

The 5-Ht1a-R Knockout Mouse As A Model Of Later Life Anxiety Disorders: Implications For Sex Differences, Tatyana Budylin

Dissertations, Theses, and Capstone Projects

Anxiety affects nearly twice as many women as it affects men across all cultures and economic groups. Importantly, girls have a higher chance of inheriting anxiety disorders than boys, and many anxiety disorders appear at a very young age. However, little is known about sex differences in brain and behavioral development and how they relate to anxiety in adulthood. Serotonin 1A receptor (5-HT_1A-R) mediated signaling has been implicated in depression and anxiety, however most studies that focus on the involvement of the 5-HT_1A-R have been conducted in adults. Little is known about how the 5-HT_{1A …}

Cognition And The Brain Of Brood Parasitic Cowbirds., David F Sherry, Mélanie F Guigueno

Psychology Publications

Cowbirds are brood parasites. Females lay their eggs in the nests of other species, which then incubate the cowbird eggs and raise the young cowbirds. Finding and returning to heterospecific nests presents cowbirds with several cognitive challenges. In some species, such as brown-headed cowbirds (Molothrus ater), females but not males search for and remember the locations of potential host nests. We describe recent research on sex differences in cognition and the hippocampus associated with this sex difference in search for host nests. Female brown-headed cowbirds perform better than males on some, but not all, tests of spatial memory and females …

Spider Brain Morphology & Behavior, Skye M. Long

Doctoral Dissertations

Spiders are ideal model animals for experimental and comparative studies of behavior, learning and perception. They display many complex behaviors, such as the multimodal mating dances of lycosid spiders, the stealthy hunting strategies of the jumping spider Portia sp., to the labile sociality of theridiids. Spiders also demonstrate a wide range of cognitive capabilities. Spiders perceive their environment using multiple sensory modalities including: chemosensory organs; lyriform and slit-sense organs and specialized hairs that detect vibration and air movement; and up to eight eyes that vary in function, some able to detect polarization and a broad spectrum of light, including …

The Brain Geography Mini-Course: A Neuroscience Outreach Effort, Mark Albert

Computer Science: Faculty Publications and Other Works

The way we experience the world - how we go between sensing, thinking, and acting - is in some ways no more of a mystery than understanding how a computer works. Brains are quite complicated and we may never understand the details, but what we know in general can be very interesting. In this mini-course, we will learn how we think. When we see, hear, smell, touch, taste, remember, rehearse, fear something, understand or produce language, move our bodies...specific parts of the brain are used. Students will get a rough introduction to each part and how they interact. This will …

Fatty Acid Induced Insulin Resistance In The Brain, Hyoung Il Oh

All Graduate Theses and Dissertations, Spring 1920 to Summer 2023

The prevalence of obesity is rapidly increasing; it is now one of the most serious public health problems worldwide. Obesity is thought to reflect the interaction between genetics and modern life style. In particular, high fat diets (HFD) are considered as a major contributing factor to the development of obesity and type 2 diabetes as well as other metabolic disorders such as cardiovascular disease, Alzheimer’s disease and some types of cancer. Recently, it has been suggested that insulin actions in the brain are important in the regulation of energy homeostasis and peripheral metabolism.

With the support of USTAR (The Utah …

A Songbird Forebrain Area Potentially Involved In Auditory Discrimination And Memory Formation, Raphael Pinaud, Thomas A. Terleph

Biology Faculty Publications

Songbirds rely on auditory processing of natural communication signals for a number of social behaviors, including mate selection, individual recognition and the rare behavior of vocal learning - the ability to learn vocalizations through imitation of an adult model, rather than by instinct. Like mammals, songbirds possess a set of interconnected ascending and descending auditory brain pathways that process acoustic information and that are presumably involved in the perceptual processing of vocal communication signals. Most auditory areas studied to date are located in the caudomedial forebrain of the songbird and include the thalamo-recipient field L (subfields L1, L2 and L3), …