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Full-Text Articles in Neuroscience and Neurobiology
Altering Sensory Learning By Chronic Inactivation Of Vip Interneurons, Christopher Alba, Hannah Selwyn, Katie Ferguson, Jessica Cardin
Altering Sensory Learning By Chronic Inactivation Of Vip Interneurons, Christopher Alba, Hannah Selwyn, Katie Ferguson, Jessica Cardin
The Yale Undergraduate Research Journal
Vasoactive intestinal polypeptide-expressing interneurons (VIP-INs) play a key role in the regulation of cortical circuits and are implicated in perceptual function and psychiatric disease. However, their role in perceptual augmentation and learning remains understudied. We performed chronic, localized ablation of VIP-INs in the primary visual cortex of adult mice using caspase-induced apoptosis to better understand how VIP-INs contribute to visual perception and the ability to learn a visual detection task. We find that chronic VIP-IN ablation does not affect naïve performance on a full-screen visual contrast detection task. However, mice with suppressed levels of VIP-INs achieved their final expert state …
Analyzing Ultrastructural Characteristics Of Post-Synaptic Targets Of Pre-Identified Presynaptic Boutons In Layer 3 And Layer 4 Of The Ferret Primary Visual Cortex, Donia Shehab
Dissertations and Theses
The purpose of this study was to analyze the size and ultrastructural characteristics of post-synaptic elements apposed to previously characterized pre-synaptic elements in layers 3 and 4 of the primary visual cortex (PVC). We are aiming to quantify a range of values for synaptic element morphologies as well as to correlate pre- and post-synaptic elements to find a set of rules that is prevalent in the visual cortex that can also be upheld in other mammals. We hypothesize that bigger pre-synaptic elements correlate to bigger synapses and bigger post-synaptic elements. We compared these two different layers because they receive synaptic …