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Full-Text Articles in Neuroscience and Neurobiology
Examining The Role Of The Drosophila Melanogaster Unc13 Protein In Open Field Activity Using Rnai, Islam Orabi
Examining The Role Of The Drosophila Melanogaster Unc13 Protein In Open Field Activity Using Rnai, Islam Orabi
Honors Theses
Unc13 are proteins in the presynaptic neurons essential in controlling synaptic vesicle fusion and synaptic transmission. Recently, the reduction of Drosophila melanogaster Unc13 proteins (Dunc13), were found to result in a resistance to alcohol, highly reminiscent of tolerance formation. I investigated whether genetically reducing Dunc13 activity in Drosophila brain regions leads to different forms of behavioral plasticity using an open field activity paradigm. In my approach, a Dunc13 RNAi transgene was expressed in the Drosophila brain within the mushroom body, the ellipsoid body, and in all neurons. The activities of the flies were examined in the open field paradigm to …
The Role Of The Dal Neurons In Modulating Circadian Rhythms In Olfactory Short-Term Memory In Drosophila Melanogaster, Cooper Ruwe
The Role Of The Dal Neurons In Modulating Circadian Rhythms In Olfactory Short-Term Memory In Drosophila Melanogaster, Cooper Ruwe
Honors Theses
Depressed short-term memory (STM) abilities during non-adaptive times of the day can significantly impact those who work occupations that require peak levels of cognitive functioning around the clock. While much work has gone into understanding the endogenous clock and circadian rhythms, there is still much to learn about the neural circuity that underlies the daily rhythms that define these regular oscillations in STM performance. The DAL neurons in the Drosophila brain are part of the circadian network and innervate the mushroom bodies (MBs), the species’ olfactory learning center, making them compelling candidates to be involved in circadian circuitry for olfactory …