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The Role Of Er-Alpha And The Ovaries In The Enduring Altered Behavioral Response To Pubertal Immune Stress, Bethany Rappleyea
The Role Of Er-Alpha And The Ovaries In The Enduring Altered Behavioral Response To Pubertal Immune Stress, Bethany Rappleyea
Masters Theses 1911 - February 2014
Peripubertal immune stress alters adult responsiveness to estradiol (E2) and progesterone (P). When female mice are injected with the bacterial endotoxin lipopolysaccharide (LPS) at six weeks of age, or during pubertal development, they display a decrease in response to ovarian hormones. In contrast, females ovariectomized prior to peripubertal immune stress display typical levels of sexual behavior following sequential injections of E2 and P in adulthood. Additionally, intact females exposed to peripubertal immune stress display a decrease in estrogen receptor alpha (ER-α)-immunoreactive (ir) cells in the medial preoptic area (MPOA) and ventromedial nucleus of the hypothalamus (VMH) in …