Microbiology Commons^™

Molecular Targets Of Manuka Honey In Human Breast Cancer, Sarah Saif Al Qubaisi

Theses

The medicinal properties of Manuka honey have been extensively studied, particularly in terms of its wound healing and antimicrobial activities. We have previously demonstrated that Manuka honey also has anti-cancer properties against a variety of cancer cell types in vitro as well as in preclinical cancer models. The cellular targets of the anti-cancer activity of Manuka honey, however, remain unknown. For the present study, we selected the triple negative human breast cancer cell line, MDA-MB-231, to investigate susceptibility to Manuka honey and to identify the potential signaling pathways affected. MDA-MB-231 cancer cells are known to constitutively express activated STAT3 transcription …