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Full-Text Articles in Microbiology
Activation Of Nf-Κb By Double-Stranded Rna (Dsrna) In The Absence Of Protein Kinase R And Rnase L Demonstrates The Existence Of Two Separate Dsrna-Triggered Antiviral Programs, Mihail S. Iordanov, John Wong, John C. Bell, Bruce E. Magun
Activation Of Nf-Κb By Double-Stranded Rna (Dsrna) In The Absence Of Protein Kinase R And Rnase L Demonstrates The Existence Of Two Separate Dsrna-Triggered Antiviral Programs, Mihail S. Iordanov, John Wong, John C. Bell, Bruce E. Magun
CUP Faculty Research
Double-stranded RNA (dsRNA) of viral origin triggers two programs of the innate immunity in virus-infected cells. One is intended to decrease the rate of host cell protein synthesis and thus to prevent viral replication. This program is mediated by protein kinase R (PKR) and by RNase L and contributes, eventually, to the self-elimination of the infected cell via apoptosis. The second program is responsible for the production of antiviral (type I) interferons and other alarmone cytokines and serves the purpose of preparing naive cells for the viral invasion. This second program requires the survival of the infected cell and depends …