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Full-Text Articles in Microbiology
The Evolution Of Bacteriophages E11/2 And E4/Lc For Control Of Verocytotxigenic E.Coli At Key Stages In The Beef Chain, Bríd Coffey
Theses
The objective of this thesis was lo evaluate the potential of bactcriophages e4/1 c and cl 1/2 ns biocontrol agents for E. coli O157:H7. Initially, e4/lc and el 1/2 were subjected to high-throughput 454 sequencing. The data generated revealed that e4/I c (47,112 bp) is very similar to the lytic E. coli phages RTP and JK06. Interestingly, differences within the tail module led to the identification of a putative site of attachment to E. coli O157:H?. Comparative genomic analysis indicated that el 1/2 (168,470 bp) is a novel member of the T-even group, with high degrees of similarity to T4 …