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Full-Text Articles in Microbiology
Metabolomic And Genomic Analysis Of Lactobacillus Crispatus Vaginal Isolates, Emiley Watson
Metabolomic And Genomic Analysis Of Lactobacillus Crispatus Vaginal Isolates, Emiley Watson
Electronic Thesis and Dissertation Repository
Lactobacillus crispatus is the dominant species in the vagina of many women. To add to our knowledge of its properties, the metabolic readout of twenty strains was analyzed using liquid chromatography-mass spectrometry (LC-MS). This led to a separation of the strains into two groups, Groups A and B. Notably, five Group B strains produced tyramine, known to raise vaginal pH, and make the environment more favourable to vaginal pathogens. The origin of Group B strains did not correlate with their host having bacterial vaginosis (BV), a condition associated with elevated pH. Five bacteriocins were detected in the genomes. Therefore, differences …
Recombinase-Based In Vivo Expression Technology Identifies A Streptococcus Pyogenes Bacteriocin Important For Niche Adaptation In The Nasopharynx, Brent D. Armstrong
Recombinase-Based In Vivo Expression Technology Identifies A Streptococcus Pyogenes Bacteriocin Important For Niche Adaptation In The Nasopharynx, Brent D. Armstrong
Electronic Thesis and Dissertation Repository
Streptococcus pyogenes is a Gram-positive, human-specific bacterial pathogen with the ability to cause a wide range of diseases from strep throat to necrotizing fasciitis and toxic shock syndrome. In addition, S. pyogenes may also induce post-streptococcal sequelae including rheumatic fever, acute glomerulonephritis, and reactive arthritis. Although primarily recognized as a pathogen, S. pyogenes also colonizes the skin and throat often without causing disease, and while numerous surface adhesions are important to attach to these surfaces, additional factors important for colonization and persistence by S. pyogenes are poorly understood. In addition to host defence mechanisms, the upper respiratory tract also contains …