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2012

Neuronal Death

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Q-Ve-Oph, A Control Caspase Inhibitor For Analyzing Neuronal Death, Rebecca L. Bricker Jan 2012

Q-Ve-Oph, A Control Caspase Inhibitor For Analyzing Neuronal Death, Rebecca L. Bricker

Browse all Theses and Dissertations

Sarin is a neurotoxin that has been used in terrorist attacks in Japan and is a potential bioterrorist weapon. It induces seizures by affecting the regulation of neurotransmitters in the brain. Seizures are directly correlated to neuronal damage. Two types of neuronal damage that can occur are apoptosis and necrosis. One of the main regions of the brain where neuronal death occurs is the hippocampus, which is involved in memory. Victims showed chronic decline of memory loss 3 and 7 years after the Tokyo's terrorist attack incident. There are treatments available that can break down sarin or can block the …