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Application Of Genetic Techniques To Investigate Chlamydia Trachomatis Type Iii Secretion Effector Biology, Gabrielle Keb
Application Of Genetic Techniques To Investigate Chlamydia Trachomatis Type Iii Secretion Effector Biology, Gabrielle Keb
Theses and Dissertations--Microbiology, Immunology, and Molecular Genetics
Chlamydia trachomatis is the causative agent of the most reported bacterial sexually transmitted disease in the United States. The establishment of an intracellular niche within mucosal epithelium is sufficient to drive immunopathology and disease sequela. As obligate intracellular bacteria, Chlamydia spp. have evolved numerous mechanisms for establishing an intracellular growth environment. The type III secretion system (T3SS) delivers effector proteins to the host cytosol and is essential for C. trachomatis invasion and development. The effectors TmeA, TmeB, and TarP, are all secreted during C. trachomatis invasion. TarP and TmeA have been associated with manipulation of actin networks and are …