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Full-Text Articles in Microbiology
Investigation Of Host Responses Upon Infection Of Distinct Toxoplasma Strains, Rachel Devonne Hill
Investigation Of Host Responses Upon Infection Of Distinct Toxoplasma Strains, Rachel Devonne Hill
Doctoral Dissertations
Toxoplasma gondii is the causative agent of Toxoplasmosis in human and animals. T. gondii isolates are highly diverse. Hundreds of genotypes have been identified, but only three clonal lineages, namely Type I, II and III are prevalent worldwide. In mouse model, T. gondii strains can be divided into three groups based on their virulence, including the virulent (LD100=1), the intermediately virulent (LD50 = 103-104) and the non virulent (LD50 > 105). The clonal Type I, II and III T. gondii strains belong to these three groups, respectively. Epidemiologic studies suggest the …
Study Of Population Diversity Of Toxoplasma Gondii, Debashree Majumdar
Study Of Population Diversity Of Toxoplasma Gondii, Debashree Majumdar
Masters Theses
Toxoplasma gondii, the causal agent of toxoplasmosis, is an important water and food borne protozoan parasite. T. gondii was previously shown to have a distinct clonal population structure composed of Type I, II and III lineages in North America and Europe. But more recent studies demonstrated high diversity in South America. In the present project we have conducted an intensive study of the population diversity of T. gondii and surveyed the extent of genetic variation among natural T. gondii isolates on a global scale in order to better understand the population dynamics and pathogenesis of this parasite. To this …