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Full-Text Articles in Microbiology
Novobiocin As An Allosteric Modulator Of Ste2p, Jeffrey K. Rymer, Melinda Hauser, Jeffrey M. Becker
Novobiocin As An Allosteric Modulator Of Ste2p, Jeffrey K. Rymer, Melinda Hauser, Jeffrey M. Becker
EURēCA: Exhibition of Undergraduate Research and Creative Achievement
G protein-coupled receptors (GPCRs) are the target of 30-50% of all prescribed drugs for human medicine and are therefore the subject of intense study by the scientific community. It has been recognized recently that compounds called allosteric modulators can regulate GPCR activity by binding a GPCR at sites not occupied by the normal receptor-activating molecule. Such allosteric compounds are desirable drug candidates as they may produce fewer toxic side-effects than standard drugs that target GPCRs. The purpose of this study was to determine the interaction of different allosteric modulators with Ste2p, a model GPCR expressed in the yeast Saccharomyces cerevisiae. …