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Full-Text Articles in Marine Biology
Functional Activation Of Cartilaginous Fish Melanocortin Receptors, Christina Lee Reinick
Functional Activation Of Cartilaginous Fish Melanocortin Receptors, Christina Lee Reinick
Electronic Theses and Dissertations
The evolution of the melanocortin receptor (MCR) gene family has been dictated by two genome duplication events (2R hypothesis). The gnathostomes are thus predicted to possess a minimum of four MCR genes. Previous studies on cartilaginous fish have shown evidence for the presence of only three MCRs. The purpose of this thesis is to functionally express the MC5R from the spiny dogfish (Squalus acanthias) and the putative MC2R and MC3R from the elephant shark (Callorhinchus milii); these receptors have not yet been fully characterized. In this study, SacMC5R was able to be expressed in CHO cells …