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Full-Text Articles in Laboratory and Basic Science Research
Stiffness And Modulus And Independent Controllers Of Breast Cancer Metastasis, Dannielle Ryman
Stiffness And Modulus And Independent Controllers Of Breast Cancer Metastasis, Dannielle Ryman
Masters Theses 1911 - February 2014
One out of eight women in the United States will develop breast cancer during their lifetime. Ninety percent of cancer related deaths are due to metastasis. Metastasis is the biological process where individual or aggregate cancerous cells break away from the primary tumor site and colonize distant, non-adjacent locations throughout the body. It is my objectives to study how mechanical, topographical and biochemical cues affect metastatic breast cancer metastasis at an early developmental stage. ECM components have previously been shown to affect cell motility via ligand-receptor interactions, and physical cues, such as matrix stiffness and protein density. The primary tumor …
Regulation Of Crbp1 In Mammary Epithelial Cells, Stacy L. Pease
Regulation Of Crbp1 In Mammary Epithelial Cells, Stacy L. Pease
Masters Theses 1911 - February 2014
Breast cancer is the second leading cause of death of women in the United States, warranting further investigation into preventative therapies. It has been well documented that early pregnancy results in a lifetime decreased risk of breast cancer in humans and mounting evidence suggests that the retinoic acid pathway may play an important role in this protective effect. Cellular retinol binding protein-1 (CRBP1) is an essential component of the retinoic acid pathway and we propose that it plays an important role in pregnancy-induced protection against breast cancer. In order to investigate the role of CRBP1 in parity-induced protection against breast …