Open Access. Powered by Scholars. Published by Universities.®
Laboratory and Basic Science Research Commons™
Open Access. Powered by Scholars. Published by Universities.®
- Discipline
-
- Animal Experimentation and Research (1)
- Biochemical Phenomena, Metabolism, and Nutrition (1)
- Biochemistry (1)
- Biochemistry, Biophysics, and Structural Biology (1)
- Biology (1)
-
- Cell Biology (1)
- Cell and Developmental Biology (1)
- Cellular and Molecular Physiology (1)
- Diseases (1)
- Endocrine System Diseases (1)
- Endocrinology (1)
- Medical Immunology (1)
- Medical Sciences (1)
- Medicine and Health Sciences (1)
- Molecular Biology (1)
- Nutritional and Metabolic Diseases (1)
- Other Cell and Developmental Biology (1)
- Physiological Processes (1)
- Physiology (1)
- Research Methods in Life Sciences (1)
- Translational Medical Research (1)
Articles 1 - 2 of 2
Full-Text Articles in Laboratory and Basic Science Research
Cul3 Negatively Regulates Nlrp12-Mediated Inhibition Of The Canonical Nf-Κb Signaling Pathway, Inyeong Lee
Cul3 Negatively Regulates Nlrp12-Mediated Inhibition Of The Canonical Nf-Κb Signaling Pathway, Inyeong Lee
MSU Graduate Theses
Nod-like receptor family pyrin domain-containing protein 12 (NLRP12) is mainly known for its inhibitory function on NF-κB signaling in innate immune cells, and more recently, for its ability to regulate chemokine signaling and ubiquitination of the immune receptor RIG-I. Through a yeast 2-hybrid screen, the Lupfer lab previously discovered that NLRP12 interacts with other ubiquitin-associated proteins including Cullin 3 (CUL3) and RING finger protein 2 (RNF2). This research was conducted to mainly investigate the interaction between NLRP12 and CUL3 in human cells and examine the role in regulating NF-κB signaling. Previously, co-immunoprecipitation, followed by western blot analysis, and confocal microscopy …
Modulation Of Glucose Homeostasis By Nucleotide P2y2 Receptor And Biological Sex, Hailee Anne Marino
Modulation Of Glucose Homeostasis By Nucleotide P2y2 Receptor And Biological Sex, Hailee Anne Marino
MSU Graduate Theses
Recent insights into the pathological role of Nucleotide P2Y2 receptor suggest P2Y2R involvement in high fat diet-induced obesity and potentiates insulin resistance. However, these recent insights do not demonstrate how P2Y2R modulates glucose homeostasis under physiological conditions. Further, it remains unknown how sex biological factors influence P2Y2R receptor signaling in the regulation of glucose homeostasis. The research objective for the present study is to elucidate the novel roles of P2Y2 in fasting blood glucose and glucose tolerance (basal insulin sensitivity) under resting conditions in males and females. We expected that under physiological …