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Laboratory and Basic Science Research Commons™
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Articles 1 - 4 of 4
Full-Text Articles in Laboratory and Basic Science Research
Alternatives To Laboratory Animals: Definition And Discussion, Andrew N. Rowan
Alternatives To Laboratory Animals: Definition And Discussion, Andrew N. Rowan
Andrew N. Rowan, DPhil
The origins of the concept of "alternatives" to the use of animals in research may be traced back to the 1800's and the furore about using live animals in surgical and other experiments. Some of the animal protection societies in England were prepared to accept animal experimentation provided it was performed under anesthesia. Even Dr. Marshall Hall, who championed the spread of experimental medicine in 19th century England, considered it necessary to control and prevent unwarranted, inept and cruel experimentation (French, 1975). The concept of alternatives has developed in the 20th century to encompass not only the reduction (prevention) of …
Investigation Of Zebrafish Larvae Behavior As Precursor For Suborbital Flights: Feasibility Study, Pedro Llanos, Kristina Andrijauskaite, Mark Rubinstein, Sherine S.L. Chan
Investigation Of Zebrafish Larvae Behavior As Precursor For Suborbital Flights: Feasibility Study, Pedro Llanos, Kristina Andrijauskaite, Mark Rubinstein, Sherine S.L. Chan
Pedro J. Llanos (www.AstronauticsLlanos.com)
Mapping Molecular Datasets Back To The Brain Regions They Are Extracted From: Remembering The Native Countries Of Hypothalamic Expatriates And Refugees, Arshad M. Khan, Alice H. Grant, Anais Martinez, Gully Apc Burns, Brendan S. Thatcher, Vishwanath T. Anekonda, Benjamin W. Thompson, Zachary S. Roberts, Daniel H. Moralejo, James E. Blevins
Mapping Molecular Datasets Back To The Brain Regions They Are Extracted From: Remembering The Native Countries Of Hypothalamic Expatriates And Refugees, Arshad M. Khan, Alice H. Grant, Anais Martinez, Gully Apc Burns, Brendan S. Thatcher, Vishwanath T. Anekonda, Benjamin W. Thompson, Zachary S. Roberts, Daniel H. Moralejo, James E. Blevins
Arshad M. Khan, Ph.D.
History Of The 3rs In Toxicity Testing: From Russell And Burch To 21st Century Toxicology, Martin L. Stephens, Nina S. Mak
History Of The 3rs In Toxicity Testing: From Russell And Burch To 21st Century Toxicology, Martin L. Stephens, Nina S. Mak
Martin Stephens, PhD
Toxicity testing is a key part of the process of assessing the hazards, safety, or risk that chemicals and other substances pose to humans, animals, or the environment. Standardized methods for such testing, typically involving animals, began to emerge during the first half of the 20th century. In 1959, British scientists William Russell and Rex Burch proposed a framework for reducing, refining, or replacing animal use in toxicology and other forms of biomedical experimentation. This “3Rs” or “alternatives” approach emerged at a time of growing sensitivity to the use of animals in experimentation, and progress in its implementation has been …