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Full-Text Articles in Laboratory and Basic Science Research
Chitosan-Cellulose Composite For Wound Dressing Material. Part 2. Antimicrobial Activity, Blood Absorption Ability, And Biocompatibility, April Harkins, Simon Duri, Luther C. Kloth, Chieu D. Tran
Chitosan-Cellulose Composite For Wound Dressing Material. Part 2. Antimicrobial Activity, Blood Absorption Ability, And Biocompatibility, April Harkins, Simon Duri, Luther C. Kloth, Chieu D. Tran
Clinical Lab Sciences Faculty Research and Publications
Chitosan (CS), a polysaccharide derived from chitin, the second most abundant polysaccharide, is widely used in the medical world because of its natural and nontoxic properties and its innate ability for antibacterial and hemostasis effects. In this study, the novel composites containing CS and cellulose (CEL) (i.e., [CEL + CS]), which we have previously synthesized using a green and totally recyclable method, were investigated for their antimicrobial activity, absorption of anticoagulated whole blood, anti-inflammatory activity through the reduction of tumor necrosis factor-α (TNF-α) and interleukin-6 (IL-6), and the biocompatibility with human fibroblasts. The [CEL + CS] composites were found to …
In Vitro Effects Of Two Silver Electrodes On Select Wound Pathogens, Linda Jean Laatsch-Lybeck, Poh Chye Ong, Luther C. Kloth
In Vitro Effects Of Two Silver Electrodes On Select Wound Pathogens, Linda Jean Laatsch-Lybeck, Poh Chye Ong, Luther C. Kloth
Physical Therapy Faculty Research and Publications
The use of electrical current to promote wound healing is well documented. However, little is understood about the effects of micro-amperage direct current (μADC) on growth of wound pathogens. The purpose of this project was to investigate the antibacterial effects of a silver wire/silver nylon electrode carrying μADC in vitro on several Gram positive and Gram negative bacteria. The current was delivered via silver wire and silver nylon electrodes at an amplitude of 100 μA for a 30-minute duration in an in vitro system. Results demonstrated that only silver wire carrying current inhibited bacterial growth around …
Antibacterial Effects Of A Silver Electrode Carrying Microamperage Direct Current In Vitro, Poh Chye Young, Luther C. Kloth, Linda Jean Laatsch-Lybeck
Antibacterial Effects Of A Silver Electrode Carrying Microamperage Direct Current In Vitro, Poh Chye Young, Luther C. Kloth, Linda Jean Laatsch-Lybeck
Physical Therapy Faculty Research and Publications
Currently, electrical stimulation is an accepted method used clinically to promote chronic wound healing. A literature review revealed that similar therapeutic current has been shown to suppress growth of common wound pathogens in vitro and in vivo. To date, little has been reported on the factors contributing to the antibacterial effects of microamperage direct current (μADC) stimulation. The purpose of this project was to investigate the role of electric field strength, current density, pH, and type of electrode used in vitro, to gain a better understanding of how these factors contribute to inhibiting growth of select wound pathogens. …