Laboratory and Basic Science Research Commons^™

Results Of A Local Combination Therapy Antibiogram For Pseudomonas Aeruginosa Isolates: Is Double Worth The Trouble?, Matthew Song, Thomas J. Dilworth, Erik Munson, Jim Davis, Ramy Elshaboury

Clinical Lab Sciences Faculty Research and Publications

Purpose:

To determine the frequency at which fluoroquinolones and aminoglycosides demonstrate in vitro activity against non-urinary, non-skin/skin structure Pseudomonas aeruginosa isolates exhibiting decreased susceptibilities to one or more β-lactam agents.

Methods:

β-lactam-non-susceptible P. aeruginosa isolates recovered from blood, bone, lower respiratory tract, pleural fluid, cerebrospinal fluid, or peritoneal fluid cultures between October 2010 and October 2014 were reviewed from four community hospitals within a single health-system. Only the first isolate per patient was included for analysis. The likelihood that each isolate was susceptible to a non-β-lactam antimicrobial was then determined and summarized within a combination antibiogram.

Results:

In total, 179 …