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Full-Text Articles in Laboratory and Basic Science Research
Strategies For Reducing Control Group Size In Experiments Using Live Animals, Matthew Kramer, Enrique Font
Strategies For Reducing Control Group Size In Experiments Using Live Animals, Matthew Kramer, Enrique Font
Conference on Applied Statistics in Agriculture
Reducing the number of animal subjects used in biomedical experiments is desirable for both ethical and practical reasons. Previous suggestions for reducing sample sizes in these experiments have focused on improving experimental designs and methods of statistical analysis; reducing the number of controls (thus, the number of overall animals used) is rarely mentioned. We discuss how the number of current control animals can be reduced, without loss of statistical power, by incorporating information from historical controls, i.e. animals used as controls in similar previous experiments. Using example data from the literature, we describe how to incorporate information from historical controls …
Can Acute Dermal Systemic Toxicity Tests Be Replaced With Oral Tests? A Comparison Of Route-Specific Systemic Toxicity And Hazard Classifications Under The Globally Harmonized System Of Classification And Labelling Of Chemicals (Ghs), Nigel P. Moore, David J. Andrew, Donald L. Bjerke, Stuart Creton, David Dreher, Thomas Holmes, Pilar Prieto, Troy Seidle, Tim G. Rowan
Can Acute Dermal Systemic Toxicity Tests Be Replaced With Oral Tests? A Comparison Of Route-Specific Systemic Toxicity And Hazard Classifications Under The Globally Harmonized System Of Classification And Labelling Of Chemicals (Ghs), Nigel P. Moore, David J. Andrew, Donald L. Bjerke, Stuart Creton, David Dreher, Thomas Holmes, Pilar Prieto, Troy Seidle, Tim G. Rowan
Troy Seidle, PhD
Acute systemic toxicity data (LD50 values) and hazard classifications derived in the rat following oral administration and dermal application have been analysed to examine whether or not orally-derived hazard classification or LD50 values can be used to determine dermal hazard classification. Comparing the oral and dermal classifications for 335 substances derived from oral and dermal LD50 values respectively revealed 17% concordance, and indicated that 7% of substances would be classified less severely while 76% would be classified more severely if oral classifications were applied directly to the dermal route. In contrast, applying the oral LD50 values within the dermal classification …