Laboratory and Basic Science Research Commons^™

Microplastics In Local Communities’ Tap Water, Zachary T. Rattell

Masters Theses

Microplastics are an emerging environmental contaminant. One of the ways microplastics can get into the environment is by the breakdown of larger plastics. These plastics can come from industrial practices, discarded fabrics, agriculture, and general plastic waste. As these plastics are broken down microplastics leach into the environment. The widespread use of plastics has resulted in the spread of microplastic contaminants all over the world. Microplastics have been reported to be in drinking water, so this paper is looking at the presence of microplastics in local communities of different demographics and socioeconomic statuses. In other studies of different drinking water …

International Conference On Cancer Health Disparities, Juhi Rais, Asif Jafri, Neelam Shivnath, Habiba Khan, Md Arshad

Research Symposium

Background: Biochanin A, an isoflavone that is mainly present in red clover, has potent chemopreventive properties against many cancers. Ovarian carcinoma is fifth most common and deadliest gynaecological malignancy that causes the highest mortality in females worldwide. Hence a substantial need for new therapies for combating this gynaecological malignancy arises.

Methods: The present study aimed to investigate anti-cancerous potentials of biochanin A on cultured human ovarian carcinoma PA-1 cells through the cell viability assay, cellular apoptosis, disruption of mitochondrial membrane potential (MMP), involvement of ROS, cell cycle kinetics, and expression of apoptosis-related genes namely, p53, Bax, Bcl-2, Noxa and Puma. …

Human Health Risk Assessment Of Some Heavy Metals In Eme River, Umuahia, Abia State, Nigeria, Emeka Donald Anyanwu, Onyinyechi Gladys Adetunji, Paschal Emeka Etusim, Solomon Nnanna Umeham

Journal of Bioresource Management

This study evaluated the health risk of some heavy metals in Eme River, Umuahia. The study conducted in 6 stations was between December 2017 and November 2018. The non-carcinogenic method that involves determination of chronic daily intake (CDI), hazard quotient (HQ) and hazard index (HI) was applied in the assessment of ingestion, dermal and incidental ingestion exposures. Iron, lead and cadmium exceeded their limits and warranted risk assessment. The heavy metals’ CDI values for the three routes were lower than their respective reference doses except for cadmium (ingestion route). Except for cadmium (ingestion), the hazard quotients also recorded values lower …

Modeling Biphasic, Non-Sigmoidal Dose-Response Relationships: Comparison Of Brain- Cousens And Cedergreen Models For A Biochemical Dataset, Venkat D. Abbaraju, Tamaraty L. Robinson, Brian P. Weiser

Rowan-Virtua School of Osteopathic Medicine Faculty Scholarship

Biphasic, non-sigmoidal dose-response relationships are frequently observed in biochemistry and pharmacology, but they are not always analyzed with appropriate statistical methods. Here, we examine curve fitting methods for “hormetic” dose-response relationships where low and high doses of an effector produce opposite responses. We provide the full dataset used for modeling, and we provide the code for analyzing the dataset in SAS using two established mathematical models of hormesis, the Brain-Cousens model and the Cedergreen model. We show how to obtain and interpret curve parameters such as the ED50 that arise from modeling, and we discuss how curve parameters might change …

Migratory Material: Epigenetics & Weaving At The Us-Mexico Border, Valerie Navarrete

Masters Theses

Discourse often sutures the body shut, disallowing representations of identity to outgrow sociopolitical interests. This issue may originate from borders, but also from the unnamable pathology that generational colonial trauma transmits to the mind, body, and environment. Without a direct form of translatability, this thesis proposes a new materialism that deviates from any object-oriented ontology. Untethered and intra-active, epigenetics and weaving represent objects that transform typical ways of knowing and seeing. Their sensitivity to the environment, in addition to their mobility across generations of time, broaden the spatiotemporal loci of the body and its embodiment. Proposing new materials that expand …

Development Of A Method For Identifying And Quantifying Epicatechin In Cinnamon Extract Supplement Capsules, Danielle Valls

Annual Research Symposium

No abstract provided.

Examining The Oxidative Stress Effects In Rats Exposed To 2-Aminoanthracene In Utero And High Fat Diet Three Months After, Brianna A. Lanoix

Honors College Theses

Polycyclic aromatic hydrocarbons are organic compounds that are created synthetically or found in partially burned oil, gasoline, and coal. 2-aminoanthracene (2AA) is a common example of a PAH and can affect lipid and carbohydrate metabolism and resulting in inflammatory problems and oxidative stress. The objective of the research project is to investigate oxidative stress in relation to diabetes in rats exposed to 2AA in utero and a high fat diet later in life. Pregnant dams were separated into treatment groups based on their dosages of 2AA; 0 mg/kg (control), 50 mg/kg (low), 100 mg/kg (high). During the gestation -postpartum period, …