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Laboratory and Basic Science Research Commons™
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Articles 1 - 4 of 4
Full-Text Articles in Laboratory and Basic Science Research
In Silico Identification Of Small Molecule Agonist Binding Sites On Kcc2, Kenyon Mitchell, Alfred Amendolara, Ruth Hunter, Jaden Miner, Andrew Payne
In Silico Identification Of Small Molecule Agonist Binding Sites On Kcc2, Kenyon Mitchell, Alfred Amendolara, Ruth Hunter, Jaden Miner, Andrew Payne
Annual Research Symposium
Purpose: Potassium-Chloride Cotransporter 2 (KCC2) is a neuronal membrane protein specific to the central nervous system. It is responsible for removing Cl- ions from the intracellular space, maintaining a normal Cl- gradient essential for proper function at inhibitory synapses. Dysregulation causes an upward shift in the Cl- reversal potential resulting in a hyperexcitable state of the postsynaptic neuron. Existing literature indicates that KCC2 may be involved in the addiction pathway of a variety of drugs of abuse, including opioids and alcohol. This makes KCC2 an attractive potential drug target when treating substance use disorders. A novel direct KCC2 agonist, VU0500469, …
Exploring The Developmental Effects Of Antidepressants In Caenorhabditis Elegans, Alexandra Van Stone
Exploring The Developmental Effects Of Antidepressants In Caenorhabditis Elegans, Alexandra Van Stone
Annual Research Symposium
It is so important to explore the potential side effects of antidepressants especially if these side effects could lead to a future detriment to an individual’s financial and social well-being. A better understanding of these side effects in regards to human developmental issues is imperative considering issues related to mental health and depression affect a large percentage of the population. In this study, we tested if Caenorhabditis (C.) elegans could be a potential model organism to predict possible side effects associated with select antidepressants. Their developmental problems potentially encountered upon drug treatment may be encountered in humans.
Trkb Activity Alters Voluntary Alcohol Consumption In Nondependent Mice, Alfred Amendolara
Trkb Activity Alters Voluntary Alcohol Consumption In Nondependent Mice, Alfred Amendolara
Annual Research Symposium
No abstract provided.
Novel Methodology For The Investigation Of Dmrt3a Interneurons In Larval Zebrafish, Alfred Amendolara
Novel Methodology For The Investigation Of Dmrt3a Interneurons In Larval Zebrafish, Alfred Amendolara
Annual Research Symposium
No abstract provided.