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Effects Of High-Load Eccentric Exercise Training On Rat Soleus Muscle Myofibrillar Disruption Following One-Week Of Hindlimb Suspension Unloading And Subsequent Reloading, Rhonda Dianne Prisby
Effects Of High-Load Eccentric Exercise Training On Rat Soleus Muscle Myofibrillar Disruption Following One-Week Of Hindlimb Suspension Unloading And Subsequent Reloading, Rhonda Dianne Prisby
LSU Doctoral Dissertations
Purpose: This investigation evaluated the effects of a high-load (50% body weight) eccentric exercise training protocol on reloading myofibrillar damage in soleus (SOL) and extensor digitorum longus (EDL) muscles in rats following 7 days (d) of hindlimb suspension unloading (HSU). Methods: 48 female Sprague-Dawley rats were randomly stratified to four experimental groups; exercise + hindlimb suspension unloading (ExHSU), hindlimb suspension unloading (HSU), exercise (Ex) and control (C). The ExHSU and Ex groups underwent a high-load eccentric exercise protocol for ~2.5 weeks. Following exercise training, the ExHSU and HSU groups underwent 7 d of hindlimb suspension unloading and a subsequent 16-19 …