Kinesiology Commons^™

Characterizing Endothelial Notch1 Release In Response To Changes In Vascular Wall Shear Stress, Matthew Indiana Badour

Electronic Theses and Dissertations

Murine and cell culture models have identified Notch1 as a novel endothelial mechanosensor that may exert a protective role for vascular adjustments in response to changes in vascular wall shear stress. However, in vivo studies in humans are lacking. Accordingly, we sought to characterize the concentrations of Notch1 extracellular domain (ECD) prior to, during, and following 20-min of altered shear stress in the brachial artery of ten young and healthy adults (6M/4F). Alterations in shear were induced by placing a pneumatic cuff inflated to 220mmHg around the left wrist. Cuffs were also placed below the axilla of both arms and …