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Blast Brain Injury Elevates Catecholamine Biosynthesis In The Nucleus Tractus Solitaries And Oxidative Stress In The Hypothalamus In Rats, Nihal Tumer, Stanislav Svetlov, Nataliya Kirichenko, Melissa Whidden, Benedek Erdos, Victor Prima, Alexandra Sherman, Firas H. Kobeissy, Robert Yezierski, Charles Vierck, Kevin Wang
Blast Brain Injury Elevates Catecholamine Biosynthesis In The Nucleus Tractus Solitaries And Oxidative Stress In The Hypothalamus In Rats, Nihal Tumer, Stanislav Svetlov, Nataliya Kirichenko, Melissa Whidden, Benedek Erdos, Victor Prima, Alexandra Sherman, Firas H. Kobeissy, Robert Yezierski, Charles Vierck, Kevin Wang
Kinesiology Faculty Publications
Introduction: Traumatic Brain Injury (TBI) produces major health problems impacting the lives of both military and civilian personnel. TBI disrupts autonomic function but the nature of this disruption is unknown. Following blast brain injury, we assessed selective biochemical markers for autonomic function in adult male Sprague Dawley rats. Methods: Rats were subjected to head-directed overpressure blast injury (OBI) of 358 kPa magnitude at the target. At the same time for sham controls, rats were anesthetized as the previous group but instead of OBI were exposed just to noise being placed at ~ 2 m distance from the shock tube nozzle. …