Computational Biology Commons^™

Cross-Ontology Multi-Level Association Rule Mining In The Gene Ontology., Prashanti Manda, Seval Ozkan, Hui Wang, Fiona M. Mccarthy, Susan M. Bridges

Bagley College of Engineering Publications and Scholarship

The Gene Ontology (GO) has become the internationally accepted standard for representing function, process, and location aspects of gene products. The wealth of GO annotation data provides a valuable source of implicit knowledge of relationships among these aspects. We describe a new method for association rule mining to discover implicit co-occurrence relationships across the GO sub-ontologies at multiple levels of abstraction. Prior work on association rule mining in the GO has concentrated on mining knowledge at a single level of abstraction and/or between terms from the same sub-ontology. We have developed a bottom-up generalization procedure called Cross-Ontology Data Mining-Level by …