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Computational Biology Commons™

Open Access. Powered by Scholars. Published by Universities.®

Statistical Methodology

2010

Personalized Therapy; Genomics; Forensic Biostatistics; Microarrays; NCI60; Cell Lines

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Full-Text Articles in Computational Biology

Members’ Discoveries: Fatal Flaws In Cancer Research, Jeffrey S. Morris Jan 2010

Members’ Discoveries: Fatal Flaws In Cancer Research, Jeffrey S. Morris

Jeffrey S. Morris

A recent article published in The Annals of Applied Statistics (AOAS) by two MD Anderson researchers—Keith Baggerly and Kevin Coombes—dissects results from a highly-influential series of medical papers involving genomics-driven personalized cancer therapy, and outlines a series of simple yet fatal flaws that raises serious questions about the veracity of the original results. Having immediate and strong impact, this paper, along with related work, is providing the impetus for new standards of reproducibility in scientific research.

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