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Full-Text Articles in Computational Biology
Dynamics Of Gene Networks In Cancer Research, Paul Scott
Dynamics Of Gene Networks In Cancer Research, Paul Scott
Electronic Theses and Dissertations
Cancer prevention treatments are being researched to see if an optimized treatment schedule would decrease the likelihood of a person being diagnosed with cancer. To do this we are looking at genes involved in the cell cycle and how they interact with one another. Through each gene expression during the life of a normal cell we get an understanding of the gene interactions and test these against those of a cancerous cell. First we construct a simplified network model of the normal gene network. Once we have this model we translate it into a transition matrix and force changes on …
Epistasis In Predator-Prey Relationships, Iuliia Inozemtseva
Epistasis In Predator-Prey Relationships, Iuliia Inozemtseva
Electronic Theses and Dissertations
Epistasis is the interaction between two or more genes to control a single phenotype. We model epistasis of the prey in a two-locus two-allele problem in a basic predator- prey relationship. The resulting model allows us to examine both population sizes as well as genotypic and phenotypic frequencies. In the context of several numerical examples, we show that if epistasis results in an undesirable or desirable phenotype in the prey by making the particular genotype more or less susceptible to the predator or dangerous to the predator, elimination of undesirable phenotypes and then genotypes occurs.